PMID- 9181598
OWN - NLM
STAT- MEDLINE
DCOM- 19970718
LR  - 20190905
IS  - 0901-9928 (Print)
IS  - 0901-9928 (Linking)
VI  - 80
IP  - 5
DP  - 1997 May
TI  - An appraisal of the pharmacological and toxicological effects of a single oral 
      administration of 3,4-methylenedioxymethamphetamine (MDMA) in the rat.
PG  - 207-10
AB  - This study examined some acute pharmacological and toxicological effects of 3,4 
      methylenedioxymethamphetamine (MDMA, "Ecstasy") over a range of doses (20, 40, 
      80, 160 and 320 mg/kg orally) in adult female rats. Deaths were observed from the 
      40 mg/kg MDMA group onwards. Reductions in body weight change, food and water 
      intake were found in the 80 mg/kg group, whilst food intake alone was reduced in 
      the 20 and 40 mg/kg groups. Significant hyperthermic responses were found over 
      the first 8 hr following MDMA administration which were dose-related. A 
      significant hyperactivity of approximately 9 hr duration was observed in the 20 
      mg/kg and 40 mg/kg groups, whereas there was evidence of a serotonin syndrome in 
      the higher dosage groups. Thus, acute oral administration of MDMA results in a 
      variety of measurable responses. The cause of death in this study is probably a 
      combination of serotonin syndrome and hyperthermia.
FAU - De Souza, I
AU  - De Souza I
AD  - Department of Pharmacology, University College, Galway, Ireland.
FAU - Kelly, J P
AU  - Kelly JP
FAU - Harkin, A J
AU  - Harkin AJ
FAU - Leonard, B E
AU  - Leonard BE
LA  - eng
GR  - Wellcome Trust/United Kingdom
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Denmark
TA  - Pharmacol Toxicol
JT  - Pharmacology & toxicology
JID - 8702180
RN  - 0 (Hallucinogens)
RN  - KE1SEN21RM (N-Methyl-3,4-methylenedioxyamphetamine)
SB  - IM
MH  - Administration, Oral
MH  - Animals
MH  - Body Temperature
MH  - Dose-Response Relationship, Drug
MH  - Drug Administration Schedule
MH  - Female
MH  - Hallucinogens/*pharmacology/toxicity
MH  - N-Methyl-3,4-methylenedioxyamphetamine/*pharmacology/toxicity
MH  - Rats
MH  - Rats, Sprague-Dawley
MH  - Rectum
EDAT- 1997/05/01 00:00
MHDA- 1997/05/01 00:01
CRDT- 1997/05/01 00:00
PHST- 1997/05/01 00:00 [pubmed]
PHST- 1997/05/01 00:01 [medline]
PHST- 1997/05/01 00:00 [entrez]
AID - 10.1111/j.1600-0773.1997.tb01961.x [doi]
PST - ppublish
SO  - Pharmacol Toxicol. 1997 May;80(5):207-10. doi: 
      10.1111/j.1600-0773.1997.tb01961.x.