PMID- 9182563
OWN - NLM
STAT- MEDLINE
DCOM- 19970714
LR  - 20210209
IS  - 0021-9258 (Print)
IS  - 0021-9258 (Linking)
VI  - 272
IP  - 24
DP  - 1997 Jun 13
TI  - A novel class of GABAA receptor subunit in tissues of the reproductive system.
PG  - 15346-50
AB  - A novel subunit of the gamma-aminobutyrate, type A (GABAA) receptor family has 
      been identified in human and rat tissues. The subunit displays 30-40% amino acid 
      identity with known family members and represents a distinct subunit class 
      (termed pi). Transcripts of the pi subunit were detected in several human tissues 
      and were particularly abundant in the uterus. The pi subunit protein can assemble 
      with known GABAA receptor subunits and confer unique ligand binding properties to 
      the recombinant receptors in which it combines. Most notably, the presence of the 
      pi subunit alters the sensitivity of recombinant receptors to the endogenous 
      steroid, pregnanolone. Identification of the pi subunit indicates a new target 
      for pharmacological manipulation of GABAA receptors that are located outside of 
      the central nervous system.
FAU - Hedblom, E
AU  - Hedblom E
AD  - The Institute for Genomic Research, Rockville, Maryland 20850, USA.
FAU - Kirkness, E F
AU  - Kirkness EF
LA  - eng
SI  - GENBANK/U95367
SI  - GENBANK/U95368
GR  - NS34702/NS/NINDS NIH HHS/United States
PT  - Journal Article
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - United States
TA  - J Biol Chem
JT  - The Journal of biological chemistry
JID - 2985121R
RN  - 0 (Bridged Bicyclo Compounds, Heterocyclic)
RN  - 0 (DNA, Complementary)
RN  - 0 (RNA, Messenger)
RN  - 0 (Receptors, GABA-A)
RN  - 2763-96-4 (Muscimol)
RN  - 40P7XK9392 (Flumazenil)
RN  - 70636-86-1 (tert-butylbicyclophosphorothionate)
SB  - IM
MH  - Amino Acid Sequence
MH  - Animals
MH  - Base Sequence
MH  - Binding Sites
MH  - Bridged Bicyclo Compounds, Heterocyclic/metabolism
MH  - Cloning, Molecular
MH  - DNA, Complementary
MH  - Flumazenil/metabolism
MH  - Humans
MH  - Molecular Sequence Data
MH  - Muscimol/metabolism
MH  - RNA, Messenger/genetics
MH  - Radioligand Assay
MH  - Rats
MH  - Receptors, GABA-A/chemistry/genetics/*metabolism
EDAT- 1997/06/13 00:00
MHDA- 1997/06/13 00:01
CRDT- 1997/06/13 00:00
PHST- 1997/06/13 00:00 [pubmed]
PHST- 1997/06/13 00:01 [medline]
PHST- 1997/06/13 00:00 [entrez]
AID - S0021-9258(18)39485-7 [pii]
AID - 10.1074/jbc.272.24.15346 [doi]
PST - ppublish
SO  - J Biol Chem. 1997 Jun 13;272(24):15346-50. doi: 10.1074/jbc.272.24.15346.