PMID- 9184638
OWN - NLM
STAT- MEDLINE
DCOM- 19970703
LR  - 20190826
IS  - 0165-5728 (Print)
IS  - 0165-5728 (Linking)
VI  - 76
IP  - 1-2
DP  - 1997 Jun
TI  - Detection of CSF-specific oligoclonal antibodies to recombinant JC virus VP1 in 
      patients with progressive multifocal leukoencephalopathy.
PG  - 100-4
AB  - The intrathecal synthesis of antibodies against recombinant VP1, the major 
      structural protein of JC virus (JCV), was studied in 18 patients with progressive 
      multifocal leukoencephalopathy (PML) and in 31 patients with various neurological 
      disorders. Two methods were used, the calculation of an antibody specific index 
      (ASI) on one hand and an antigen-driven immunoblotting for the detection of 
      oligoclonal antibodies on the other. Most PML patients displayed an elevated (> 
      1.5) ASI (78%) and anti-VP1 oligoclonal antibodies restricted to the 
      cerebrospinal fluid (55%). Only two other patients (one case each of multiple 
      sclerosis and of neuroborreliosis) also showed an intrathecal synthesis of 
      anti-VP1 oligoclonal antibodies, likely as a result of a 'polyspecific' reaction 
      within the central nervous system.
FAU - Sindic, C J
AU  - Sindic CJ
AD  - Laboratoire de Neurochimie, Cliniques Universitaires Saint-Luc, Universite 
      Catholique de Louvain, Brussels, Belgium. sindic@nchm.ucl.ac.be
FAU - Trebst, C
AU  - Trebst C
FAU - Van Antwerpen, M P
AU  - Van Antwerpen MP
FAU - Frye, S
AU  - Frye S
FAU - Enzensberger, W
AU  - Enzensberger W
FAU - Hunsmann, G
AU  - Hunsmann G
FAU - Luke, W
AU  - Luke W
FAU - Weber, T
AU  - Weber T
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Netherlands
TA  - J Neuroimmunol
JT  - Journal of neuroimmunology
JID - 8109498
RN  - 0 (Antibodies, Viral)
RN  - 0 (Recombinant Proteins)
RN  - 0 (Viral Structural Proteins)
SB  - IM
MH  - Antibodies, Viral/*cerebrospinal fluid
MH  - Enzyme-Linked Immunosorbent Assay
MH  - Humans
MH  - Immunoblotting
MH  - JC Virus/*immunology
MH  - Leukoencephalopathy, Progressive Multifocal/*immunology
MH  - Recombinant Proteins/immunology
MH  - Viral Structural Proteins/*immunology
EDAT- 1997/06/01 00:00
MHDA- 2000/06/01 09:00
CRDT- 1997/06/01 00:00
PHST- 1997/06/01 00:00 [pubmed]
PHST- 2000/06/01 09:00 [medline]
PHST- 1997/06/01 00:00 [entrez]
AID - S0165-5728(97)00037-4 [pii]
AID - 10.1016/s0165-5728(97)00037-4 [doi]
PST - ppublish
SO  - J Neuroimmunol. 1997 Jun;76(1-2):100-4. doi: 10.1016/s0165-5728(97)00037-4.