PMID- 9184737
OWN - NLM
STAT- MEDLINE
DCOM- 19970724
LR  - 20151119
IS  - 0095-6562 (Print)
IS  - 0095-6562 (Linking)
VI  - 68
IP  - 6
DP  - 1997 Jun
TI  - Acute mountain sickness is not altered by a high carbohydrate diet nor associated 
      with elevated circulating cytokines.
PG  - 499-503
AB  - We investigated whether a diet of increased carbohydrate content reduces the 
      symptoms of acute mountain sickness (AMS) and whether concentrations of 
      circulating cytokines rise and correlate with hypoxia and AMS. There were 19 
      healthy volunteers who ingested in randomized order both a high carbohydrate (68% 
      CHO) or normal carbohydrate (45% CHO) diet for 4 d. On the 4th d, subjects were 
      exposed to 8 h of 10% normobaric oxygen. Each subject completed the Lake Louise 
      Consensus Questionnaire (LLCQ: a questionnaire developed to quantify the common 
      symptoms and consequences of AMS) at the beginning and end of each hypoxic 
      session, at which times venous blood was obtained for the following cytokines: 
      interleukins 1 beta, 6 and 8 (IL-1 beta, IL-6, IL-8) and tumor necrosis factor 
      alpha (TNF-alpha). AMS symptoms did not differ significantly between the diets 
      (LLCQ scores: 68% CHO = 10.1 +/- 3.8 vs. 45% CHO = 10.3 +/- 4.1). Cytokine 
      concentrations did not change with hypoxia on either diet, nor did individual 
      changes correlate with AMS symptoms. We conclude that a high carbohydrate diet 
      for 4 d does not reduce the symptoms of AMS; and plasma cytokine concentrations 
      do not change with hypoxia and the development of AMS and, thus, are not likely 
      mediators of this syndrome.
FAU - Swenson, E R
AU  - Swenson ER
AD  - Department of Medicine, VA Medical Center, Seattle, WA 98108, USA.
FAU - MacDonald, A
AU  - MacDonald A
FAU - Vatheuer, M
AU  - Vatheuer M
FAU - Maks, C
AU  - Maks C
FAU - Treadwell, A
AU  - Treadwell A
FAU - Allen, R
AU  - Allen R
FAU - Schoene, R B
AU  - Schoene RB
LA  - eng
GR  - HL-45571/HL/NHLBI NIH HHS/United States
GR  - MO1-RR00037/RR/NCRR NIH HHS/United States
PT  - Clinical Trial
PT  - Journal Article
PT  - Randomized Controlled Trial
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - United States
TA  - Aviat Space Environ Med
JT  - Aviation, space, and environmental medicine
JID - 7501714
RN  - 0 (Dietary Carbohydrates)
RN  - 0 (Interleukin-1)
RN  - 0 (Interleukin-6)
RN  - 0 (Interleukin-8)
RN  - 0 (Tumor Necrosis Factor-alpha)
RN  - S88TT14065 (Oxygen)
SB  - IM
MH  - Acute Disease
MH  - Adolescent
MH  - Adult
MH  - Altitude Sickness/blood/*diet therapy/immunology
MH  - Cross-Over Studies
MH  - Dietary Carbohydrates/*therapeutic use
MH  - Female
MH  - Humans
MH  - Interleukin-1/*blood
MH  - Interleukin-6/*blood
MH  - Interleukin-8/*blood
MH  - Male
MH  - Middle Aged
MH  - Mountaineering
MH  - Oxygen/blood
MH  - Surveys and Questionnaires
MH  - Tumor Necrosis Factor-alpha/*metabolism
EDAT- 1997/06/01 00:00
MHDA- 1997/06/01 00:01
CRDT- 1997/06/01 00:00
PHST- 1997/06/01 00:00 [pubmed]
PHST- 1997/06/01 00:01 [medline]
PHST- 1997/06/01 00:00 [entrez]
PST - ppublish
SO  - Aviat Space Environ Med. 1997 Jun;68(6):499-503.