PMID- 9184798
OWN - NLM
STAT- MEDLINE
DCOM- 19970815
LR  - 20190826
IS  - 0306-3623 (Print)
IS  - 0306-3623 (Linking)
VI  - 28
IP  - 5
DP  - 1997 May
TI  - Opposite effects of sex steroids on 11 beta-hydroxysteroid dehydrogenase activity 
      in the normal and adrenalectomized rat testis.
PG  - 661-4
AB  - 1. Sex steroids have been shown to regulate the biosynthesis of 11 
      beta-hydroxysteroid dehydrogenase (11 beta-HSD). 2. In vitro studies showed that 
      oestradiol (E2) or testosterone (T) can interfere with the bioassay of enzyme 
      activity, but not progesterone (P4). 3. For in vivo studies, the activity of 11 
      beta-HSD in the testis of normal and adrenalectomized (ADX) adult male Wistar 
      rats was determined following a daily IM injection of sex steroids for 7 days. 4. 
      The 11 beta-HSD activity was significantly reduced (P < 0.01) either by E2 or T 
      in normal and ADX rats. The enzyme activity in normal rats given both T and E2 
      was even lower (P < 0.001) than when E2 was given alone. 5. P4 given to normal 
      and ADX rats increased the enzyme activity higher than normal (P < 0.001). 6. The 
      presence of corticosteroids influenced the effects of E2, but not of T and P4, on 
      11 beta-HSD activity. 7. E2 and T downregulate 11 beta-HSD activity, whereas P4 
      increased it. E2 did not act through lowering T level.
FAU - Nwe, K H
AU  - Nwe KH
AD  - Department of Physiology, Faculty of Medicine, University Kebangsaan Malaysia, 
      Jalan Raja Muda, Kuala Lumpur, Malaysia.
FAU - Morat, P B
AU  - Morat PB
FAU - Khalid, B A
AU  - Khalid BA
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - Gen Pharmacol
JT  - General pharmacology
JID - 7602417
RN  - 0 (Gonadal Steroid Hormones)
RN  - 3XMK78S47O (Testosterone)
RN  - 4G7DS2Q64Y (Progesterone)
RN  - 4TI98Z838E (Estradiol)
RN  - EC 1.1.- (Hydroxysteroid Dehydrogenases)
RN  - EC 1.1.1.146 (11-beta-Hydroxysteroid Dehydrogenases)
SB  - IM
MH  - 11-beta-Hydroxysteroid Dehydrogenases
MH  - Adrenalectomy
MH  - Animals
MH  - Body Weight/drug effects
MH  - Estradiol/pharmacology
MH  - Gonadal Steroid Hormones/*pharmacology
MH  - Hydroxysteroid Dehydrogenases/*metabolism
MH  - In Vitro Techniques
MH  - Male
MH  - Organ Size/drug effects
MH  - Progesterone/pharmacology
MH  - Rats
MH  - Rats, Wistar
MH  - Testis/*drug effects/enzymology/physiology
MH  - Testosterone/pharmacology
EDAT- 1997/05/01 00:00
MHDA- 1997/05/01 00:01
CRDT- 1997/05/01 00:00
PHST- 1997/05/01 00:00 [pubmed]
PHST- 1997/05/01 00:01 [medline]
PHST- 1997/05/01 00:00 [entrez]
AID - S0306362396003539 [pii]
AID - 10.1016/s0306-3623(96)00353-9 [doi]
PST - ppublish
SO  - Gen Pharmacol. 1997 May;28(5):661-4. doi: 10.1016/s0306-3623(96)00353-9.