PMID- 9185693
OWN - NLM
STAT- MEDLINE
DCOM- 19970708
LR  - 20190708
IS  - 0020-7136 (Print)
IS  - 0020-7136 (Linking)
VI  - 71
IP  - 6
DP  - 1997 Jun 11
TI  - Integrated Epstein-Barr virus (EBV) and chromosomal abnormality in chronic active 
      EBV infection.
PG  - 943-7
AB  - In order to examine the role of Epstein-Barr virus (EBV) in the pathogenesis of 
      chronic active EBV infection (CAEBV), we investigated whether or not EBV 
      integration into the human genome is associated with any chromosonal abnormality. 
      We therefore analyzed 4 cases of CAEBV: 2 cases showed a normal karyotype, while 
      one had an oligo-clonal 6th chromosomal abnormality and the fourth had a clonal 
      6th deletion (q15q23). In addition, the case with an oligo-clonal abnormality 
      also had oligo-clonal EBV terminal repeat (TR) bands, while the case with a 
      clonal abnormality showed a clonal TR band. In contrast, the 2 cases with a 
      normal karyotype showed no clonal band. Two-color fluorescence in situ 
      hybridization (FISH) was used to detect the integrated EBV and the 6th 
      chromosomal site. The presence of integrated EBV into the 6th chromosome was not 
      frequent in the 2 cases with a normal karyotype, but it was statistically 
      frequent in the case with an oligo-clonal 6th abnormality. In the case with a 
      clonal 6th deletion, integration in the 6th chromosome was also slightly higher 
      than that in the other chromosomes. In CAEBV, integrated EBV might thus be 
      associated both with chromosomal abnormality and with pathogenesis.
FAU - Ohshima, K
AU  - Ohshima K
AD  - Department of Pathology, School of Medicine, Fukuoka University, Jonan-ku, Japan.
FAU - Suzumiya, J
AU  - Suzumiya J
FAU - Ohga, S
AU  - Ohga S
FAU - Ohgami, A
AU  - Ohgami A
FAU - Kikuchi, M
AU  - Kikuchi M
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Int J Cancer
JT  - International journal of cancer
JID - 0042124
SB  - IM
MH  - *Chromosome Aberrations
MH  - Chronic Disease
MH  - Female
MH  - Herpesvirus 4, Human/*genetics
MH  - Humans
MH  - Karyotyping
MH  - Male
MH  - Tumor Virus Infections/*genetics/virology
MH  - *Virus Integration
EDAT- 1997/06/11 00:00
MHDA- 2000/06/20 09:00
CRDT- 1997/06/11 00:00
PHST- 1997/06/11 00:00 [pubmed]
PHST- 2000/06/20 09:00 [medline]
PHST- 1997/06/11 00:00 [entrez]
AID - 10.1002/(SICI)1097-0215(19970611)71:6<943::AID-IJC5>3.0.CO;2-Y [pii]
AID - 10.1002/(sici)1097-0215(19970611)71:6<943::aid-ijc5>3.0.co;2-y [doi]
PST - ppublish
SO  - Int J Cancer. 1997 Jun 11;71(6):943-7. doi: 
      10.1002/(sici)1097-0215(19970611)71:6<943::aid-ijc5>3.0.co;2-y.