PMID- 9186433
OWN - NLM
STAT- MEDLINE
DCOM- 19970714
LR  - 20190726
IS  - 0161-6420 (Print)
IS  - 0161-6420 (Linking)
VI  - 104
IP  - 6
DP  - 1997 Jun
TI  - Bilateral iridocyclitis with retinal capillaritis in juveniles.
PG  - 939-44
AB  - PURPOSE: The authors present clinical features of 18 juvenile patients with a new 
      type of uveitis termed bilateral iridocyclitis with retinal capillaritis (BIRC). 
      METHODS: The authors reviewed medical records of 18 consecutive patients who 
      showed bilateral iridocyclitis with retinal capillary leakage but no systemic 
      manifestations during an 11-year period from January 1985 to December 1995. 
      RESULTS: Twelve of the 18 patients were female and the age at onset ranged from 9 
      to 17 years old. All patients had many cells in the anterior chamber and anterior 
      vitreous, together with mutton fat keratic precipitates. Fluorescein angiography 
      showed leakage from the optic disc and retinal capillaries, mainly in the 
      midperiphery, which corresponded to retinal cloudiness. Macular edema was 
      minimal, and all patients maintained good vision. The inflammation responded well 
      topical, oral, and intravenous administration of corticosteroids, the choice of 
      which was based on the extent of retinal inflammation. Human leukocyte antigen 
      (HLA)-DR6 and HLA-Cw7 were associated significantly with the presence of BIRC 
      (chi square test, P < 0.0001). CONCLUSIONS: Bilateral retinal capillaritis 
      affecting capillaries in various areas of the retina and overlying retinal 
      cloudiness with no distinct lesions are unique to these patients. Fluorescein 
      angiography is essential for diagnosis of BIRC.
FAU - Matsuo, T
AU  - Matsuo T
AD  - Department of Ophthalmology, Okayama University Medical School, Japan.
FAU - Matsuo, N
AU  - Matsuo N
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Ophthalmology
JT  - Ophthalmology
JID - 7802443
RN  - 0 (Arrestin)
RN  - 0 (Biomarkers)
RN  - 0 (Glucocorticoids)
RN  - 0 (HLA-C Antigens)
RN  - 0 (HLA-C*70 antigen)
RN  - 0 (HLA-DR6 Antigen)
SB  - IM
MH  - Acute Disease
MH  - Adolescent
MH  - Arrestin/analysis
MH  - Biomarkers
MH  - Capillaries/pathology
MH  - Child
MH  - Enzyme-Linked Immunosorbent Assay
MH  - Female
MH  - Fluorescein Angiography
MH  - Follow-Up Studies
MH  - Fundus Oculi
MH  - Glucocorticoids/administration & dosage/therapeutic use
MH  - HLA-C Antigens/analysis
MH  - HLA-DR6 Antigen/analysis
MH  - Humans
MH  - Iridocyclitis/*complications/diagnosis/drug therapy
MH  - Male
MH  - Prognosis
MH  - Retinal Diseases/*complications/diagnosis/drug therapy
MH  - Retinal Vessels/pathology
MH  - Retrospective Studies
MH  - Vasculitis/*complications/diagnosis/drug therapy
MH  - Visual Acuity
EDAT- 1997/06/01 00:00
MHDA- 1997/06/01 00:01
CRDT- 1997/06/01 00:00
PHST- 1997/06/01 00:00 [pubmed]
PHST- 1997/06/01 00:01 [medline]
PHST- 1997/06/01 00:00 [entrez]
AID - S0161-6420(97)30203-6 [pii]
AID - 10.1016/s0161-6420(97)30203-6 [doi]
PST - ppublish
SO  - Ophthalmology. 1997 Jun;104(6):939-44. doi: 10.1016/s0161-6420(97)30203-6.