PMID- 9188038
OWN - NLM
STAT- MEDLINE
DCOM- 19970728
LR  - 20230315
IS  - 0895-8696 (Print)
IS  - 0895-8696 (Linking)
VI  - 8
IP  - 2
DP  - 1997 Apr
TI  - Terminal dUTP nick end labeling (TUNEL) positive cells in the different regions 
      of the brain in normal aging and Alzheimer patients.
PG  - 75-82
AB  - This study investigated terminal dUTP nick-end labeling (TUNEL)-positive cells in 
      the frontal, occipital, and hippocampal cortices of seven normal aging and four 
      Alzheimer's patients. Significant increase in TUNEL-positive cells was observed 
      in the frontal and hippocampal cortices of Alzheimer's patients when compared 
      with controls. In the hippocampal cortex, only area CA4 demonstrated a 
      significant increase of TUNEL-positive cells. Double staining of TUNEL-positive 
      cells for glial fibrillary acidic protein revealed that < 13% of the 
      TUNEL-positive nuclei belonged to astrocytes. The results of this study 
      illustrated a differential pattern of cortical degeneration between normal aging 
      and Alzheimer patients.
FAU - Li, W P
AU  - Li WP
AD  - Department of Neurology, First Military Medical University, Guangzhou, China.
FAU - Chan, W Y
AU  - Chan WY
FAU - Lai, H W
AU  - Lai HW
FAU - Yew, D T
AU  - Yew DT
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PL  - United States
TA  - J Mol Neurosci
JT  - Journal of molecular neuroscience : MN
JID - 9002991
RN  - 0 (Uracil Nucleotides)
RN  - 6SO6U10H04 (Biotin)
SB  - IM
MH  - Aged
MH  - Aged, 80 and over
MH  - Aging/*pathology
MH  - Alzheimer Disease/mortality/*pathology
MH  - Apoptosis/physiology
MH  - Astrocytes/chemistry/cytology
MH  - Biotin
MH  - Cell Nucleus/pathology
MH  - *DNA Fragmentation
MH  - Female
MH  - Humans
MH  - Male
MH  - Neurons/*chemistry/cytology
MH  - Staining and Labeling
MH  - Uracil Nucleotides/*analysis
EDAT- 1997/04/01 00:00
MHDA- 1997/04/01 00:01
CRDT- 1997/04/01 00:00
PHST- 1997/04/01 00:00 [pubmed]
PHST- 1997/04/01 00:01 [medline]
PHST- 1997/04/01 00:00 [entrez]
AID - 10.1007/BF02736774 [doi]
PST - ppublish
SO  - J Mol Neurosci. 1997 Apr;8(2):75-82. doi: 10.1007/BF02736774.