PMID- 9188090
OWN - NLM
STAT- MEDLINE
DCOM- 19970814
LR  - 20071114
IS  - 0882-4010 (Print)
IS  - 0882-4010 (Linking)
VI  - 22
IP  - 6
DP  - 1997 Jun
TI  - Bacterial phenotypes mediated by mviA and their relationship to the mouse 
      virulence of Salmonella typhimurium.
PG  - 353-62
AB  - The focus of this study was the phenotypic characterization of Salmonella 
      typhimurium mutants lacking the function of the response regulator mviA. The 
      inactivation of mviA+ (mviA::kan) is shown to induce a significant change in the 
      growth of most virulent strains, as reflected in the size of the colonies formed 
      on agar plates. The colony phenotype observed in these strains has been 
      designated as the small colony morphology (Scm+) phenotype. Mutants exhibiting 
      the Scm+ phenotype are shown to be significantly attenuated for virulence in 
      susceptible (ItyB) mice. The Scm+ phenotype therefore provides an in vitro 
      phenotypic marker for mviA+ activity. Further examination of Scm+ mutants has 
      revealed that they lack expression of a 55 kDa periplasmic protein which is 
      detected in isogenic mviA+ strains. This protein has been designated mviA+ 
      related protein A (MrpA) and was expressed in direct correlation with virulence 
      in all S. typhimurium strains examined.
FAU - Swords, W E
AU  - Swords WE
AD  - Department of Pathology, University of Alabama at Birmingham 35294-0007, USA.
FAU - Giddings, A
AU  - Giddings A
FAU - Benjamin, W H Jr
AU  - Benjamin WH Jr
LA  - eng
GR  - R01 AI15946/AI/NIAID NIH HHS/United States
GR  - T32 AI107041/AI/NIAID NIH HHS/United States
PT  - Journal Article
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - England
TA  - Microb Pathog
JT  - Microbial pathogenesis
JID - 8606191
RN  - 0 (Bacterial Proteins)
SB  - IM
MH  - Animals
MH  - Bacterial Proteins/*genetics/physiology
MH  - Cytoplasm/metabolism
MH  - Genes, Bacterial
MH  - Mice
MH  - Mice, Inbred BALB C
MH  - Mutation
MH  - Phenotype
MH  - Salmonella typhimurium/*genetics/*pathogenicity
MH  - Virulence
EDAT- 1997/06/01 00:00
MHDA- 2001/03/28 10:01
CRDT- 1997/06/01 00:00
PHST- 1997/06/01 00:00 [pubmed]
PHST- 2001/03/28 10:01 [medline]
PHST- 1997/06/01 00:00 [entrez]
AID - S0882-4010(96)90117-5 [pii]
AID - 10.1006/mpat.1996.0117 [doi]
PST - ppublish
SO  - Microb Pathog. 1997 Jun;22(6):353-62. doi: 10.1006/mpat.1996.0117.