PMID- 9188902
OWN - NLM
STAT- MEDLINE
DCOM- 19970731
LR  - 20190814
IS  - 0001-6314 (Print)
IS  - 0001-6314 (Linking)
VI  - 95
IP  - 5
DP  - 1997 May
TI  - Absence of seven human herpesviruses, including HHV-6, by polymerase chain 
      reaction in CSF and blood from patients with multiple sclerosis and optic 
      neuritis.
PG  - 280-3
AB  - Several members of the herpesvirus family have been implicated in the 
      pathogenesis of multiple sclerosis (MS). Recently, HHV-6 viral antigen has been 
      demonstrated in association to MS plaques, as well as DNA from human herpesvirus 
      6 (HHV-6) in cerebrospinal fluid from a few MS patients by polymerase chain 
      reaction (PCR). In the present study, CSF from patients with MS, optic neuritis 
      and other neurological diseases, as well as consecutive CSF and serum samples 
      from MS patients included in a clinical trial with acyclovir, were analysed by 
      nested PCR for the presence of DNA from herpes simplex virus 1 and 2, 
      Epstein-Barr virus, varicella zoster virus, cytomegalovirus, human herpesvirus 6 
      and 7. No virus DNA was found in any CSF (n = 115) or serum (n = 116) sample. 
      These findings argue against a continuous disseminated herpesvirus infection in 
      MS, but do not rule out a lesion-associated, low-grade herpesvirus infection 
      within the MS brain.
FAU - Martin, C
AU  - Martin C
AD  - Department of Neurology, Karolinska Institute, Huddinge University Hospital, 
      Stockholm, Sweden.
FAU - Enbom, M
AU  - Enbom M
FAU - Soderstrom, M
AU  - Soderstrom M
FAU - Fredrikson, S
AU  - Fredrikson S
FAU - Dahl, H
AU  - Dahl H
FAU - Lycke, J
AU  - Lycke J
FAU - Bergstrom, T
AU  - Bergstrom T
FAU - Linde, A
AU  - Linde A
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Denmark
TA  - Acta Neurol Scand
JT  - Acta neurologica Scandinavica
JID - 0370336
RN  - 0 (DNA, Viral)
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - DNA, Viral
MH  - Female
MH  - Herpesvirus 6, Human/*isolation & purification
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - *Multiple Sclerosis/blood/cerebrospinal fluid/virology
MH  - *Optic Neuritis/blood/cerebrospinal fluid/virology
MH  - *Polymerase Chain Reaction
MH  - Severity of Illness Index
EDAT- 1997/05/01 00:00
MHDA- 1997/05/01 00:01
CRDT- 1997/05/01 00:00
PHST- 1997/05/01 00:00 [pubmed]
PHST- 1997/05/01 00:01 [medline]
PHST- 1997/05/01 00:00 [entrez]
AID - 10.1111/j.1600-0404.1997.tb00210.x [doi]
PST - ppublish
SO  - Acta Neurol Scand. 1997 May;95(5):280-3. doi: 10.1111/j.1600-0404.1997.tb00210.x.