PMID- 9195165
OWN - NLM
STAT- MEDLINE
DCOM- 19970730
LR  - 20061115
IS  - 1102-4151 (Print)
IS  - 1102-4151 (Linking)
VI  - 163
IP  - 5
DP  - 1997 May
TI  - Allelic loss on chromosome 11 is uncommon in parathyroid glands of patients with 
      hypercalcaemic secondary hyperparathyroidism.
PG  - 331-7
AB  - OBJECTIVE: To test the hypothesis that progression of secondary 
      hyperparathyroidism from normocalcaemia to hypercalcaemia occurs because of 
      development of monoclonal parathyroid tumours after the inactivation of a tumour 
      suppressor gene on chromosome 11q13. DESIGN: Experimental study. SETTING: 
      University hospital, Sweden. SUBJECTS: 13 Patients with secondary hypercalcaemic 
      hyperparathyroidism. INTERVENTIONS: 48 Parathyroid glands were removed, 39 of 
      which were analysed using Southern blot hybridisation and polymerase chain 
      reaction. MAIN OUTCOME MEASURES: Loss of heterozygosity on several loci on 
      chromosome 11, including 11q13, which carries the presumed gene for multiple 
      endocrine neoplasia type 1 (MEN1). RESULTS: Monosomy for chromosome 11 was found 
      in one tumour. CONCLUSIONS: It seems unlikely that the MEN1 gene is of importance 
      in the progression of secondary hyperparathyroidism.
FAU - Farnebo, F
AU  - Farnebo F
AD  - Department of Molecular Medicine, Karolinska Hospital, Stockholm, Sweden.
FAU - Farnebo, L O
AU  - Farnebo LO
FAU - Nordenstrom, J
AU  - Nordenstrom J
FAU - Larsson, C
AU  - Larsson C
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - Eur J Surg
JT  - The European journal of surgery = Acta chirurgica
JID - 9105264
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Aged
MH  - Alleles
MH  - Child
MH  - *Chromosome Deletion
MH  - Chromosomes, Human, Pair 11/*genetics
MH  - Disease Progression
MH  - Female
MH  - Heterozygote
MH  - Humans
MH  - Hypercalcemia/etiology/genetics
MH  - Hyperparathyroidism, Secondary/complications/*genetics
MH  - Hyperplasia
MH  - Male
MH  - Middle Aged
MH  - Parathyroid Glands/pathology/*physiopathology
EDAT- 1997/05/01 00:00
MHDA- 1997/05/01 00:01
CRDT- 1997/05/01 00:00
PHST- 1997/05/01 00:00 [pubmed]
PHST- 1997/05/01 00:01 [medline]
PHST- 1997/05/01 00:00 [entrez]
PST - ppublish
SO  - Eur J Surg. 1997 May;163(5):331-7.