PMID- 9196061
OWN - NLM
STAT- MEDLINE
DCOM- 19970721
LR  - 20161124
IS  - 0006-291X (Print)
IS  - 0006-291X (Linking)
VI  - 235
IP  - 1
DP  - 1997 Jun 9
TI  - Expression of the proliferation-related Ki-67 mRNA in the early development of 
      murine embryo.
PG  - 191-6
AB  - In a search for early lymphoid-specific genes, we isolated a cDNA clone (LL7) 
      encoding a murine homologue of Ki-67 protein, a proliferation-related nuclear 
      antigen. LL7 transcript appears preferentially in lymphoid organs as the bone 
      marrow, spleen, and the thymus. Here, we studied the expression of murine Ki-67 
      (mKi-67) mRNA among various organs or tissues during the early development of 
      fetus. In fetus, mKi-67 mRNA appears developmentally as early as day 11 and is 
      expressed maximally at day 15. In situ hybridization on the section revealed that 
      the expression of mKi-67 mRNA is preferential in the area of active organ 
      formation such as neurological system and the fetal liver. These results suggest 
      that mKi-67 plays an important role in the proliferation of early embryonic 
      precursor cells of neurological and immune systems.
FAU - Mitsuyoshi, S
AU  - Mitsuyoshi S
AD  - Department of Immunology, Kumamoto University School of Medicine, Honjo, Japan.
FAU - Igarashi, H
AU  - Igarashi H
FAU - Sakata, A
AU  - Sakata A
FAU - Koseki, H
AU  - Koseki H
FAU - Taniguchi, M
AU  - Taniguchi M
FAU - Sakaguchi, N
AU  - Sakaguchi N
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Biochem Biophys Res Commun
JT  - Biochemical and biophysical research communications
JID - 0372516
RN  - 0 (DNA-Binding Proteins)
RN  - 0 (Ki-67 Antigen)
RN  - 0 (Nuclear Proteins)
RN  - 0 (PAX5 Transcription Factor)
RN  - 0 (Pax5 protein, mouse)
RN  - 0 (RNA, Messenger)
RN  - 0 (Transcription Factors)
SB  - IM
MH  - Animals
MH  - Blotting, Northern
MH  - Brain/embryology/metabolism
MH  - Cell Differentiation/genetics
MH  - Cells, Cultured
MH  - DNA-Binding Proteins/genetics
MH  - Embryo, Mammalian/*metabolism
MH  - Embryonic and Fetal Development/*genetics
MH  - *Gene Expression Regulation, Developmental
MH  - In Situ Hybridization
MH  - Ki-67 Antigen/*genetics
MH  - Liver/embryology/metabolism
MH  - Lymphoid Tissue/embryology/metabolism
MH  - Mice
MH  - Mice, Inbred BALB C
MH  - Nuclear Proteins/genetics
MH  - PAX5 Transcription Factor
MH  - RNA, Messenger/genetics/*metabolism
MH  - Stem Cells/metabolism
MH  - *Transcription Factors
MH  - Transcription, Genetic
EDAT- 1997/06/09 00:00
MHDA- 1997/06/09 00:01
CRDT- 1997/06/09 00:00
PHST- 1997/06/09 00:00 [pubmed]
PHST- 1997/06/09 00:01 [medline]
PHST- 1997/06/09 00:00 [entrez]
AID - S0006-291X(97)96759-0 [pii]
AID - 10.1006/bbrc.1997.6759 [doi]
PST - ppublish
SO  - Biochem Biophys Res Commun. 1997 Jun 9;235(1):191-6. doi: 10.1006/bbrc.1997.6759.