PMID- 9196616
OWN - NLM
STAT- MEDLINE
DCOM- 19970708
LR  - 20190813
IS  - 0300-0664 (Print)
IS  - 0300-0664 (Linking)
VI  - 46
IP  - 4
DP  - 1997 Apr
TI  - Cystic glucagonoma with loss of heterozygosity on chromosome 11 in multiple 
      endocrine neoplasia type 1.
PG  - 511-6
AB  - A 52-year-old man with a past history of a pituitary adenoma and 
      hyperparathyroidism due to a parathyroid adenoma was admitted because of a 
      solitary tumour of the pancreas revealed by ultrasonography. His family history 
      was unremarkable. Plasma glucagon levels were slightly elevated (280 ng/l, normal 
      range, 40-180 ng/l) with decreased plasma amino acid levels. Plasma glucagon 
      levels disclosed an exaggerated response during an arginine infusion test and 
      paradoxical elevation during a 75 g oral glucose tolerance test. Endoscopic 
      ultrasonography revealed a monolocular cystic mass of about 3 cm in diameter in 
      the body of the pancreas. A pancreatic tumour was diagnosed before surgery as a 
      cystic glucagonoma. Intra-operative ultrasonography showed one cystic mass in the 
      body of pancreas and two other solid tumours, about 1 cm and 0.5 cm in diameter, 
      in the tail of the pancreas. Histologically, all three tumours showed neoplastic 
      epithelial cells with round nuclei forming cords and/or a ribbon-like 
      arrangement. They showed positive staining for Grimelius' silver stain and 
      immunopositive cells for glucagon. Genetic analysis of the main cystic tumour 
      revealed loss of heterozygosity (LOH) on chromosome 11. After the operation, the 
      responses of plasma glucagon to arginine infusion and oral glucose became normal. 
      Here we describe the usefulness of these provocation tests for early diagnosis 
      and post-operative follow-up in a rare cystic glucagonoma associated with 
      multiple endocrine neoplasia type 1 (MEN 1) which had LOH on chromosome 11.
FAU - Sarui, H
AU  - Sarui H
AD  - Third Department of Internal Medicine, Gifu University School of Medicine, Japan.
FAU - Yoshimoto, K
AU  - Yoshimoto K
FAU - Okumura, S
AU  - Okumura S
FAU - Kamura, M
AU  - Kamura M
FAU - Takuno, H
AU  - Takuno H
FAU - Ishizuka, T
AU  - Ishizuka T
FAU - Takao, H
AU  - Takao H
FAU - Shimokawa, K
AU  - Shimokawa K
FAU - Itakura, M
AU  - Itakura M
FAU - Saji, S
AU  - Saji S
FAU - Yasuda, K
AU  - Yasuda K
LA  - eng
PT  - Case Reports
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - Clin Endocrinol (Oxf)
JT  - Clinical endocrinology
JID - 0346653
RN  - 9007-92-5 (Glucagon)
RN  - 94ZLA3W45F (Arginine)
SB  - IM
MH  - Arginine
MH  - *Chromosomes, Human, Pair 11
MH  - Glucagon/blood
MH  - Glucagonoma/diagnosis/diagnostic imaging/*genetics
MH  - Glucose Tolerance Test
MH  - *Homozygote
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Multiple Endocrine Neoplasia Type 1/diagnostic imaging/*genetics
MH  - Pancreatic Neoplasms/diagnosis/diagnostic imaging/*genetics
MH  - Ultrasonography
EDAT- 1997/04/01 00:00
MHDA- 1997/04/01 00:01
CRDT- 1997/04/01 00:00
PHST- 1997/04/01 00:00 [pubmed]
PHST- 1997/04/01 00:01 [medline]
PHST- 1997/04/01 00:00 [entrez]
AID - 10.1046/j.1365-2265.1997.1380965.x [doi]
PST - ppublish
SO  - Clin Endocrinol (Oxf). 1997 Apr;46(4):511-6. doi: 
      10.1046/j.1365-2265.1997.1380965.x.