PMID- 9198288
OWN - NLM
STAT- MEDLINE
DCOM- 19970915
LR  - 20150901
IS  - 0578-1337 (Print)
IS  - 0578-1337 (Linking)
VI  - 59
IP  - 3
DP  - 1997 Mar
TI  - Hyperdynamic circulation in prehepatic portal hypertension: role of tumor 
      necrosis factor-alpha.
PG  - 145-50
AB  - BACKGROUND: Portal hypertension is associated with a hyperdynamic circulation 
      characterized by increased cardiac output and reduced systemic vascular 
      resistance. Tumor necrosis factor-alpha (TNF-alpha) is a peptide mediator 
      released by mononuclear cells on activation by endotoxin, tissue injury and 
      malignancy. This cytokine induces vasodilatation by activating nitric oxide 
      synthesis. The aim of this study is to investigate if TNF-alpha is involved in 
      the pathogenesis of hyperdynamic circulation observed in portal vein-ligated 
      (PVL) rats. METHODS: Systemic and portal hemodynamics were determined in seven 
      PVL and five sham-operated (SHAM) rats using a thermodilution technique. In 
      addition, plasma TNF-alpha concentrations were determined in another 34 PVL and 
      16 SHAM rats using commercially available enzyme-linked immunosorbent assay. 
      RESULTS: PVL rats had a significantly lower mean arterial pressure (109 +/- 17 
      mmHg vs. 133 +/- 12 mmHg, p < 0.001) and systemic vascular resistance (2.5 +/- 
      0.6 mmHg.ml-1.min.100 g BW vs. 4.6 +/- 0.8 mmHg.ml-1.min.100 g BW, p < 0.001) 
      accompanied by a significantly higher portal pressure (14 +/- 1.9 mmHg vs. 9 +/- 
      2.1 mmHg, p < 0.001) and cardiac index (47.0 +/- 12.1 ml.min-1.100 g BW-1 vs. 
      29.3 +/- 3.5 ml.min-1.100 g BW-1, p < 0.001) when compared with SHAM rats. Also, 
      PVL rats had significantly higher plasma levels of TNF-alpha as compared with 
      SHAM rats (13.8 +/- 0.9 pg/ ml vs. 11.1 +/- 0.5 pg/ml, p < 0.05). CONCLUSIONS: 
      This study suggests that elevated plasma levels of TNF-alpha observed in PVL rats 
      may participate in the development and/or maintenance of the hyperdynamic 
      circulation occurring in prehepatic portal hypertension.
FAU - Chu, C J
AU  - Chu CJ
AD  - Department of Medicine, Veterans General Hospital-Taipei, Taiwan, R.O.C.
FAU - Lee, F Y
AU  - Lee FY
FAU - Chang, F Y
AU  - Chang FY
FAU - Wang, S S
AU  - Wang SS
FAU - Lin, H C
AU  - Lin HC
FAU - Wu, S L
AU  - Wu SL
FAU - Tai, C C
AU  - Tai CC
FAU - Lee, S D
AU  - Lee SD
LA  - eng
PT  - Journal Article
PL  - China (Republic : 1949- )
TA  - Zhonghua Yi Xue Za Zhi (Taipei)
JT  - Zhonghua yi xue za zhi = Chinese medical journal; Free China ed
JID - 0005327
RN  - 0 (Tumor Necrosis Factor-alpha)
SB  - IM
MH  - Animals
MH  - Blood Pressure
MH  - Cardiac Output
MH  - *Hemodynamics
MH  - Hypertension, Portal/*etiology/physiopathology
MH  - Male
MH  - Rats
MH  - Rats, Wistar
MH  - Tumor Necrosis Factor-alpha/*physiology
MH  - Vascular Resistance
EDAT- 1997/03/01 00:00
MHDA- 1997/03/01 00:01
CRDT- 1997/03/01 00:00
PHST- 1997/03/01 00:00 [pubmed]
PHST- 1997/03/01 00:01 [medline]
PHST- 1997/03/01 00:00 [entrez]
PST - ppublish
SO  - Zhonghua Yi Xue Za Zhi (Taipei). 1997 Mar;59(3):145-50.