PMID- 9200281
OWN - NLM
STAT- MEDLINE
DCOM- 19970812
LR  - 20190814
IS  - 0036-5521 (Print)
IS  - 0036-5521 (Linking)
VI  - 32
IP  - 6
DP  - 1997 Jun
TI  - Peptic ulcer perforation before and after the introduction of H2-receptor 
      blockers and proton pump inhibitors.
PG  - 523-9
AB  - BACKGROUND: The aim of this retrospective study was to compare patients treated 
      for perforated peptic ulcer before and after the introduction of the H2-receptor 
      antagonists and proton pump inhibitors (PPI) with regard to their medical 
      history, clinical features, methods of diagnosis and treatment, complications, 
      and mortality. METHODS AND RESULTS: During the study period 1974 to 1992 we found 
      a significant reduction in the incidence of peptic ulcer perforation (P < 0.001). 
      Patients admitted during the later period of the study were older and more 
      seriously ill. The incidence of perforation among men decreased, but that among 
      women was stable, thus changing the sex ratio towards a female preponderance at 
      the end of the study period. After the introduction of PPI the relative number of 
      gastric perforations decreased compared with the number of perforations in the 
      duodenum. A relatively higher proportion of patients with gastric perforations 
      was taking acetylsalicylic acid or non-steroid, anti-inflammatory drugs at the 
      time of admission compared with patients with duodenal perforation. Simple suture 
      of the perforation was the operative procedure used in 80% of the patients. 
      CONCLUSIONS: Even though patients were increasingly older and more ill, neither 
      the mortality nor the rate of postoperative complications changed during the 
      study period.
FAU - Hermansson, M
AU  - Hermansson M
AD  - Dept. of Surgery, Lund University Hospital, Sweden.
FAU - Stael von Holstein, C
AU  - Stael von Holstein C
FAU - Zilling, T
AU  - Zilling T
LA  - eng
PT  - Journal Article
PL  - England
TA  - Scand J Gastroenterol
JT  - Scandinavian journal of gastroenterology
JID - 0060105
RN  - 0 (Anti-Ulcer Agents)
RN  - 0 (Histamine H2 Antagonists)
RN  - 0 (Proton Pump Inhibitors)
SB  - IM
EIN - Scand J Gastroenterol 1997 Oct;32(10):1072
MH  - Age Factors
MH  - Aged
MH  - Anti-Ulcer Agents/*therapeutic use
MH  - Case-Control Studies
MH  - Duodenal Ulcer/*complications
MH  - Female
MH  - Histamine H2 Antagonists/*therapeutic use
MH  - Humans
MH  - Incidence
MH  - Male
MH  - Middle Aged
MH  - Peptic Ulcer Perforation/*epidemiology/prevention & control/surgery
MH  - Postoperative Complications/epidemiology
MH  - *Proton Pump Inhibitors
MH  - Retrospective Studies
MH  - Sex Distribution
MH  - Sex Factors
MH  - Stomach Ulcer/*complications
MH  - Sweden/epidemiology
EDAT- 1997/06/01 00:00
MHDA- 1997/06/01 00:01
CRDT- 1997/06/01 00:00
PHST- 1997/06/01 00:00 [pubmed]
PHST- 1997/06/01 00:01 [medline]
PHST- 1997/06/01 00:00 [entrez]
AID - 10.3109/00365529709025093 [doi]
PST - ppublish
SO  - Scand J Gastroenterol. 1997 Jun;32(6):523-9. doi: 10.3109/00365529709025093.