PMID- 9200431
OWN - NLM
STAT- MEDLINE
DCOM- 19970714
LR  - 20181130
IS  - 0022-1767 (Print)
IS  - 0022-1767 (Linking)
VI  - 159
IP  - 1
DP  - 1997 Jul 1
TI  - IL-4 secretion by CD4+ NK1+ T cells induces monocyte chemoattractant protein-1 in 
      early listeriosis.
PG  - 7-10
AB  - IL-4 is a major promotor of Th2 differentiation and an antagonist of IFN-gamma 
      production. Although experimental listeriosis is characterized by a Th1 response, 
      IL-4-producing cells were detected in spleens of mice promptly after Listeria 
      monocytogenes infection. We identified this early IL-4 as inducer of the 
      chemokine, monocyte chemoattractant protein-1 (MCP-1), which mainly attracts 
      monocytes/macrophages, but not neutrophils. MCP-1-secreting cells were 
      demonstrable in spleens of mice infected with L. monocytogenes, and IL-4 
      neutralization with anti-IL-4 mAb 11B11 markedly diminished frequencies of 
      MCP-1-producing cells. Cell depletion experiments and studies with gene 
      disruption mutant mice lacking distinct T cell subsets and surface MHC molecules 
      point to CD4+ NK1+ T cells as a cellular source of early IL-4. Since monocyte 
      infiltration to infective foci contributes to early control of listeriosis, our 
      results suggest that IL-4-producing CD4+ NK1+ T cells participate in the innate 
      immune response against L. monocytogenes through MCP-1 induction.
FAU - Flesch, I E
AU  - Flesch IE
AD  - Department of Immunology, University of Ulm, Germany. 
      Inge.Flesch@Medizin.Uni-Ulm.De
FAU - Wandersee, A
AU  - Wandersee A
FAU - Kaufmann, S H
AU  - Kaufmann SH
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - J Immunol
JT  - Journal of immunology (Baltimore, Md. : 1950)
JID - 2985117R
RN  - 0 (CD4 Antigens)
RN  - 0 (Chemokine CCL2)
RN  - 207137-56-2 (Interleukin-4)
SB  - IM
MH  - Animals
MH  - CD4 Antigens/immunology
MH  - Chemokine CCL2/*immunology
MH  - Immunity
MH  - Interleukin-4/*immunology/metabolism
MH  - Killer Cells, Natural/*immunology
MH  - Listeriosis/*immunology
MH  - Mice
MH  - Mice, Inbred C57BL
EDAT- 1997/07/01 00:00
MHDA- 1997/07/01 00:01
CRDT- 1997/07/01 00:00
PHST- 1997/07/01 00:00 [pubmed]
PHST- 1997/07/01 00:01 [medline]
PHST- 1997/07/01 00:00 [entrez]
PST - ppublish
SO  - J Immunol. 1997 Jul 1;159(1):7-10.