PMID- 9201371
OWN - NLM
STAT- MEDLINE
DCOM- 19970911
LR  - 20190822
IS  - 0105-4538 (Print)
IS  - 0105-4538 (Linking)
VI  - 52
IP  - 5
DP  - 1997 May
TI  - Anisakis simplex, a relevant etiologic factor in acute urticaria.
PG  - 576-9
AB  - Anisakis simplex, a parasite of fish and cephalopods, can induce IgE-mediated 
      reactions. This study aimed to determine the etiologic role of A. simplex in 
      patients affected by urticaria/angioedema (AE) or anaphylaxis. We studied 100 
      adult subjects suffering acute episodes of urticaria/AE, by anamnesis, prick 
      tests with A. simplex and fish-mix extracts, and total and specific IgE to both 
      A. simplex and cod. The following criteria of A. simplex allergy were considered: 
      1) urticaria/AE within 6 h after fish ingestion; 2) specific IgE to A. simplex; 
      3) positive prick test to A. simplex extract; 4) exclusion of other suspected 
      causes. Double-blind, placebo-controlled food challenge was not carried out 
      because ethical considerations forbid challenge with a parasite. Specific IgE to 
      A. simplex (> 0.7 kU/l) was found in 22 subjects, but only eight were diagnosed 
      as having A. simplex allergy. Other allergens were involved in 37 patients, and 
      55 cases were considered idiopathic. Specific IgE to fish (> 0.7 kU/l) was found 
      in two patients, but only one was diagnosed as having fish allergy. We concluded 
      that A. simplex is an important etiologic factor in acute urticaria. We suggest 
      that it should be considered in cases of urticaria/AE or anaphylaxis, especially 
      after fish ingestion.
FAU - Del Pozo, M D
AU  - Del Pozo MD
AD  - Department of Allergy and Immunology, Hospital Santiago Apostol, Vitoria-Gasteiz, 
      Spain.
FAU - Audicana, M
AU  - Audicana M
FAU - Diez, J M
AU  - Diez JM
FAU - Munoz, D
AU  - Munoz D
FAU - Ansotegui, I J
AU  - Ansotegui IJ
FAU - Fernandez, E
AU  - Fernandez E
FAU - Garcia, M
AU  - Garcia M
FAU - Etxenagusia, M
AU  - Etxenagusia M
FAU - Moneo, I
AU  - Moneo I
FAU - Fernandez de Corres, L
AU  - Fernandez de Corres L
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Denmark
TA  - Allergy
JT  - Allergy
JID - 7804028
RN  - 0 (Antibodies, Helminth)
RN  - 0 (Antigens, Helminth)
RN  - 0 (Tissue Extracts)
RN  - 37341-29-0 (Immunoglobulin E)
RN  - 820484N8I3 (Histamine)
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Aged
MH  - Anaphylaxis/*etiology
MH  - Angioedema/*etiology
MH  - Animals
MH  - Anisakis/*immunology
MH  - Antibodies, Helminth/analysis/immunology
MH  - Antigens, Helminth/immunology
MH  - Female
MH  - Fishes/immunology
MH  - Food Hypersensitivity/*etiology
MH  - Histamine/pharmacology
MH  - Humans
MH  - Immunoglobulin E/analysis/immunology
MH  - Immunologic Memory
MH  - Male
MH  - Middle Aged
MH  - Seafood/adverse effects
MH  - Skin Tests
MH  - Tissue Extracts/immunology
EDAT- 1997/05/01 00:00
MHDA- 1997/05/01 00:01
CRDT- 1997/05/01 00:00
PHST- 1997/05/01 00:00 [pubmed]
PHST- 1997/05/01 00:01 [medline]
PHST- 1997/05/01 00:00 [entrez]
AID - 10.1111/j.1398-9995.1997.tb02603.x [doi]
PST - ppublish
SO  - Allergy. 1997 May;52(5):576-9. doi: 10.1111/j.1398-9995.1997.tb02603.x.