PMID- 9202966
OWN - NLM
STAT- MEDLINE
DCOM- 19970814
LR  - 20190905
IS  - 0721-832X (Print)
IS  - 0721-832X (Linking)
VI  - 235
IP  - 6
DP  - 1997 Jun
TI  - Hyperimmunoglobulinemia D in idiopathic retinal vasculitis.
PG  - 372-8
AB  - BACKGROUND: We examined four patients who exhibited both idiopathic retinal 
      vasculitis and elevated serum IgD levels. Uveitis caused by Behcet's disease is 
      also associated with high levels of serum IgD. Therefore, the clinical features 
      of these patients were investigated and the possible relationship between retinal 
      vasculitis and elevated serum IgD was examined after undertaking a study of 
      increased IgD levels in patients diagnosed with uveitis. METHODS: The study 
      population was composed of 110 patients: 49 with Behcet's disease, 15 with 
      sarcoidosis, 10 with Vogt-Koyanagi-Harada disease, and 36 with other forms of 
      uveitis. IgD measurements were performed using modifications of the latex 
      photometric immunoassay. Surface IgD (sIgD) expression in peripheral lymphocytes 
      was determined by immunofluorescence, and the correlation between serum IgD 
      levels and the percentage of sIgD-positive cells was examined. RESULTS: Twelve of 
      the 110 patients had an elevated serum IgD. Eight of the 12 had Behcet's disease, 
      and 4 were diagnosed with idiopathic retinal vasculitis. These 4 patients were 
      HLA-A24+ females whose ages ranged from 8 to 25 years. A linear correlation 
      between the serum IgD levels and the percentage of sIgD-positive cells was found. 
      CONCLUSION: Hyperimmunoglobulinemia D state was found in Behcet's disease and 
      idiopathic retinal vasculitis. These diseases may represent a new clinical entity 
      characterized by signs of retinal vasculitis and hyperimmunoglobulinemia D that 
      results from abnormal B cell activation and immune complex-mediated responses.
FAU - Kumano, Y
AU  - Kumano Y
AD  - Department of Ophthalmology, Faculty of Medicine, Kyushu University, Fukuoka, 
      Japan.
FAU - Nagato, T
AU  - Nagato T
FAU - Kurihara, K
AU  - Kurihara K
FAU - Kikukawa, H
AU  - Kikukawa H
FAU - Goto, M
AU  - Goto M
FAU - Kawano, Y
AU  - Kawano Y
FAU - Ohnishi, Y
AU  - Ohnishi Y
FAU - Inomata, H
AU  - Inomata H
LA  - eng
PT  - Case Reports
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Germany
TA  - Graefes Arch Clin Exp Ophthalmol
JT  - Graefe's archive for clinical and experimental ophthalmology = Albrecht von 
      Graefes Archiv fur klinische und experimentelle Ophthalmologie
JID - 8205248
RN  - 0 (Antibodies, Anti-Idiotypic)
RN  - 0 (HLA-A Antigens)
RN  - 0 (HLA-A24 Antigen)
RN  - 0 (Immunoglobulin D)
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Antibodies, Anti-Idiotypic/immunology
MH  - Child
MH  - Female
MH  - Fluorescein Angiography
MH  - Follow-Up Studies
MH  - Fundus Oculi
MH  - HLA-A Antigens/immunology
MH  - HLA-A24 Antigen
MH  - Humans
MH  - Hypergammaglobulinemia/blood/*complications/diagnosis
MH  - *Immunoglobulin D/blood/immunology
MH  - Lymphocytes/immunology
MH  - Male
MH  - Middle Aged
MH  - Retinal Artery/*pathology
MH  - Retinal Diseases/blood/*complications/diagnosis
MH  - Retrospective Studies
MH  - Vasculitis/blood/*complications/diagnosis
EDAT- 1997/06/01 00:00
MHDA- 1997/06/01 00:01
CRDT- 1997/06/01 00:00
PHST- 1997/06/01 00:00 [pubmed]
PHST- 1997/06/01 00:01 [medline]
PHST- 1997/06/01 00:00 [entrez]
AID - 10.1007/BF00937286 [doi]
PST - ppublish
SO  - Graefes Arch Clin Exp Ophthalmol. 1997 Jun;235(6):372-8. doi: 10.1007/BF00937286.