PMID- 9205112
OWN - NLM
STAT- MEDLINE
DCOM- 19970902
LR  - 20061115
IS  - 0888-7543 (Print)
IS  - 0888-7543 (Linking)
VI  - 42
IP  - 3
DP  - 1997 Jun 15
TI  - A transcript map encompassing the multiple endocrine neoplasia type-1 (MEN1) 
      locus on chromosome 11q13.
PG  - 405-12
AB  - A transcription map of a 1200-kb region encompassing the MEN1 locus was 
      constructed by direct cDNA selection and mapping ESTs. A total of 29 genes were 
      mapped. Ten transcripts were identified by cDNA selection of a focused 300-kb 
      genomic region telomeric to the MEN1 consensus region. Since many of the 
      sequences cloned by cDNA selection also identified ESTs from the region, 19 
      additional RH-mapped ESTs were mapped to the entire contig region by PCR 
      amplification of genomic clones. Nine known genes, 2 putative human homologues to 
      mouse genes, and 18 novel transcripts map to the region. Transcripts that map to 
      the MEN1 interval PYGM-D11S449 include SGC35223, IB1256, AA147620, ZFM1, FAU, and 
      CAPN1. The latter 3 known genes have already been excluded as candidate MEN1 
      genes. The 2 putative human homologues of mouse genes Ltbp2 and Spa-1 may be 
      candidate tumor suppressor genes, but they map telomeric to D11S449. Although 
      both of these genes map outside the MEN1 consensus region they may play a role in 
      sporadic endocrine tumors independent of the MEN1 gene or in other tumors, such 
      as breast cancer, that have loss of heterozygosity within this region.
FAU - Sawicki, M
AU  - Sawicki M
AD  - Department of Surgery Molecular Biology Core Unit, West Los Angeles Veterans 
      Administration Medical Center, California 90073, USA. msawicki@ucla.edu
FAU - Arnold, E
AU  - Arnold E
FAU - Ebrahimi, S
AU  - Ebrahimi S
FAU - Duell, T
AU  - Duell T
FAU - Jin, S
AU  - Jin S
FAU - Wood, T
AU  - Wood T
FAU - Chakrabarti, R
AU  - Chakrabarti R
FAU - Peters, J
AU  - Peters J
FAU - Wan, Y
AU  - Wan Y
FAU - Samara, G
AU  - Samara G
FAU - Weier, H U
AU  - Weier HU
FAU - Udar, N
AU  - Udar N
FAU - Passaro, E Jr
AU  - Passaro E Jr
FAU - Srivatsan, E S
AU  - Srivatsan ES
LA  - eng
SI  - GENBANK/U80781
SI  - GENBANK/U80782
SI  - GENBANK/U80783
SI  - GENBANK/U80784
SI  - GENBANK/U80785
SI  - GENBANK/U80786
SI  - GENBANK/U80963
SI  - GENBANK/U80964
SI  - GENBANK/U80965
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Research Support, U.S. Gov't, Non-P.H.S.
PL  - United States
TA  - Genomics
JT  - Genomics
JID - 8800135
RN  - 0 (MEN1 protein, human)
RN  - 0 (Neoplasm Proteins)
RN  - 0 (Proto-Oncogene Proteins)
SB  - IM
MH  - Blotting, Northern
MH  - Chromosome Mapping
MH  - *Chromosomes, Human, Pair 11
MH  - Humans
MH  - In Situ Hybridization, Fluorescence
MH  - Multiple Endocrine Neoplasia Type 1/*genetics
MH  - Neoplasm Proteins/*genetics
MH  - *Proto-Oncogene Proteins
MH  - Sequence Analysis, DNA
MH  - Transcription, Genetic
EDAT- 1997/06/15 00:00
MHDA- 2001/03/28 10:01
CRDT- 1997/06/15 00:00
PHST- 1997/06/15 00:00 [pubmed]
PHST- 2001/03/28 10:01 [medline]
PHST- 1997/06/15 00:00 [entrez]
AID - S0888-7543(97)94773-X [pii]
AID - 10.1006/geno.1997.4773 [doi]
PST - ppublish
SO  - Genomics. 1997 Jun 15;42(3):405-12. doi: 10.1006/geno.1997.4773.