PMID- 9205793
OWN - NLM
STAT- MEDLINE
DCOM- 19970904
LR  - 20190719
IS  - 0361-9230 (Print)
IS  - 0361-9230 (Linking)
VI  - 43
IP  - 1
DP  - 1997
TI  - Changes in the albumin binding of tryptophan during postoperative recovery: a 
      possible link with central fatigue?
PG  - 43-6
AB  - Tryptophan is the precursor of the neurotransmitter 5-hydroxytryptamine (5-HT), 
      known to be involved in sleep and fatigue. In the blood, tryptophan binds to 
      albumin, and that which does not, free tryptophan, competes with branched chain 
      amino acids (BCAA) for entry into the brain. The plasma concentrations of 
      albumin, free tryptophan, total tryptophan, and BCAA were measured before and 
      after major surgery in nine elderly and nine coronary artery bypass graft (CABG) 
      patients. In both the elderly and the CABG patients plasma free tryptophan 
      concentrations were increased after surgery, compared with baseline levels; the 
      plasma free tryptophan/BCAA concentration ratio was also increased significantly 
      after surgery. Plasma albumin concentrations were decreased significantly after 
      surgery in both the elderly and the CABG patients. Plasma BCAA concentrations 
      were not affected by surgery in either group. The effect of exercising to 
      exhaustion on 5-HT and tryptophan were investigated in Nagase analbuminemic rats 
      (NAR). The intrasynaptosomal concentration of tryptophan, 5-hydroxy-tryptophan, 
      and 5-HT was increased by fatigue after exercise. In addition, running time to 
      exhaustion was shortened in NAR. These data suggest that free tryptophan uptake 
      and 5-HT synthesis were enhanced in the nerve terminal. A decrease in plasma 
      albumin may account for the increase in plasma-free tryptophan levels. An 
      increase in plasma free tryptophan, resulting in an enhanced plasma concentration 
      ratio of free tryptophan/BCAA, may lead to a higher 5-HT concentration in some 
      parts of the brain and, consequently, to central fatigue. It is suggested that 
      provision of BCAA as a dietary supplement may counteract the increase in plasma 
      free tryptophan and thus improve the status of some patients after major surgery.
FAU - Yamamoto, T
AU  - Yamamoto T
AD  - University Department of Biochemistry, Oxford, UK.
FAU - Castell, L M
AU  - Castell LM
FAU - Botella, J
AU  - Botella J
FAU - Powell, H
AU  - Powell H
FAU - Hall, G M
AU  - Hall GM
FAU - Young, A
AU  - Young A
FAU - Newsholme, E A
AU  - Newsholme EA
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Brain Res Bull
JT  - Brain research bulletin
JID - 7605818
RN  - 0 (Amino Acids, Branched-Chain)
RN  - 0 (Serum Albumin)
RN  - 333DO1RDJY (Serotonin)
RN  - 8DUH1N11BX (Tryptophan)
SB  - IM
EIN - Brain Res Bull 1997;44(6):735
MH  - Aged
MH  - Aged, 80 and over
MH  - Amino Acids, Branched-Chain/*blood
MH  - Animals
MH  - *Coronary Artery Bypass
MH  - Corpus Striatum/metabolism/ultrastructure
MH  - Fatigue/*blood
MH  - Female
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Postoperative Period
MH  - Protein Binding
MH  - Rats
MH  - Retrospective Studies
MH  - Serotonin/metabolism
MH  - Serum Albumin/deficiency/genetics/*metabolism
MH  - Synaptosomes/metabolism
MH  - Tryptophan/*metabolism
EDAT- 1997/01/01 00:00
MHDA- 1997/01/01 00:01
CRDT- 1997/01/01 00:00
PHST- 1997/01/01 00:00 [pubmed]
PHST- 1997/01/01 00:01 [medline]
PHST- 1997/01/01 00:00 [entrez]
AID - S0361-9230(96)00344-9 [pii]
AID - 10.1016/s0361-9230(96)00344-9 [doi]
PST - ppublish
SO  - Brain Res Bull. 1997;43(1):43-6. doi: 10.1016/s0361-9230(96)00344-9.