PMID- 9206096
OWN - NLM
STAT- MEDLINE
DCOM- 19970730
LR  - 20041117
IS  - 0366-6999 (Print)
IS  - 0366-6999 (Linking)
VI  - 109
IP  - 7
DP  - 1996 Jul
TI  - The role of human leukocyte antigen in susceptibility and clinical manifestations 
      of sarcoidosis.
PG  - 515-8
AB  - OBJECTIVE: To investigate the correlation of human leukocyte antigen (HLA) with 
      susceptibility and clinical manifestations of sarcoidosis. MATERIAL AND METHODS: 
      Fifty-five patients with sarcoidosis and one hundred and six normal subjects were 
      investigated. Genomic DNAs were purified using the proteinase K-phenol extraction 
      method. DNA samples were amplified by the polymerase chain reaction (PCR) 
      procedure using the DRB1 group specific primer pairs. RESULTS: The gene frequency 
      of HLA-DR5 increased significantly in patients with sarcoidosis (P < 0.01), and 
      HLA-DR7 decreased (P < 0.05). Gene frequencies of HLA-DR9 and HLA-DR5 increased 
      remarkably in male patients and in patients with stage I and stage IIa, 
      respectively (both P < 0.05). CONCLUSIONS: It is suggested that HLA-DR gene might 
      contribute to the susceptibility as well as various clinical manifestations of 
      sarcoidosis.
FAU - Xu, Z
AU  - Xu Z
AD  - Department of Respiratory Medicine, Peking Union Medical College (PUMC) Hospital, 
      Beijing.
FAU - Zhao, Y
AU  - Zhao Y
FAU - Zhu, X
AU  - Zhu X
FAU - Qiu, C
AU  - Qiu C
FAU - Luo, W
AU  - Luo W
FAU - Zhu, Y
AU  - Zhu Y
LA  - eng
PT  - Journal Article
PL  - China
TA  - Chin Med J (Engl)
JT  - Chinese medical journal
JID - 7513795
RN  - 0 (HLA-DR5 Antigen)
RN  - 0 (HLA-DR7 Antigen)
SB  - IM
MH  - Adult
MH  - Aged
MH  - CD4-Positive T-Lymphocytes/immunology
MH  - Disease Susceptibility
MH  - Female
MH  - Gene Frequency
MH  - HLA-DR5 Antigen/genetics/*physiology
MH  - HLA-DR7 Antigen/genetics/*physiology
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Sarcoidosis, Pulmonary/*genetics
EDAT- 1996/07/01 00:00
MHDA- 1996/07/01 00:01
CRDT- 1996/07/01 00:00
PHST- 1996/07/01 00:00 [pubmed]
PHST- 1996/07/01 00:01 [medline]
PHST- 1996/07/01 00:00 [entrez]
PST - ppublish
SO  - Chin Med J (Engl). 1996 Jul;109(7):515-8.