PMID- 9209001
OWN - NLM
STAT- MEDLINE
DCOM- 19970724
LR  - 20190822
IS  - 0361-8609 (Print)
IS  - 0361-8609 (Linking)
VI  - 55
IP  - 2
DP  - 1997 Jun
TI  - Reinterpretation of G-banded complex karyotypes by fluorescence in situ 
      hybridization with chromosome-specific DNA painting probes and alpha-satellite 
      centromere-specific DNA probes in malignant hematological disorders.
PG  - 69-76
AB  - In this study, we have performed fluorescence in situ hybridization (FISH) with 
      chromosome-specific DNA painting probes 1, 2, 3, 4, 6, 8, and 12 and 
      centromere-specific DNA probes 7,10,12,17,18, and X after G-banding on the same 
      metaphase spreads from four patients with malignant hematological disorders to 
      more precisely interpret their complex karyotypes. The findings demonstrated that 
      the application of combined G-banding and FISH can more accurately explain 
      complex karyotypes of hematological malignancies. FISH can detect not only the 
      origin of marker chromosomes, but also the complex rearrangements that cannot be 
      identified by routine banding techniques. This approach is very important to 
      complement the cytogenetic analysis of malignant disorders and to evaluate the 
      role of chromosome change in the development, progression, and prognosis of 
      tumors.
FAU - Shi, G
AU  - Shi G
AD  - Department of Oncology/Hematology, University Hospital Eppendorf, University of 
      Hamburg, Germany.
FAU - Weh, H J
AU  - Weh HJ
FAU - Hossfeld, D K
AU  - Hossfeld DK
LA  - eng
PT  - Case Reports
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Am J Hematol
JT  - American journal of hematology
JID - 7610369
RN  - 0 (DNA Probes)
RN  - 0 (DNA, Satellite)
SB  - IM
MH  - Chromosome Banding/*methods
MH  - DNA Probes
MH  - *DNA, Satellite
MH  - Female
MH  - Humans
MH  - In Situ Hybridization, Fluorescence/*methods
MH  - Leukemia, Lymphocytic, Chronic, B-Cell/genetics/*pathology
MH  - Leukemia, Myeloid, Acute/genetics/*pathology
MH  - Lymphoma, B-Cell/genetics/*pathology
MH  - Male
MH  - Middle Aged
EDAT- 1997/06/01 00:00
MHDA- 2000/06/20 09:00
CRDT- 1997/06/01 00:00
PHST- 1997/06/01 00:00 [pubmed]
PHST- 2000/06/20 09:00 [medline]
PHST- 1997/06/01 00:00 [entrez]
AID - 10.1002/(SICI)1096-8652(199706)55:2<69::AID-AJH4>3.0.CO;2-0 [pii]
AID - 10.1002/(sici)1096-8652(199706)55:2<69::aid-ajh4>3.0.co;2-0 [doi]
PST - ppublish
SO  - Am J Hematol. 1997 Jun;55(2):69-76. doi: 
      10.1002/(sici)1096-8652(199706)55:2<69::aid-ajh4>3.0.co;2-0.