PMID- 9209395
OWN - NLM
STAT- MEDLINE
DCOM- 19970807
LR  - 20161124
IS  - 0887-6924 (Print)
IS  - 0887-6924 (Linking)
VI  - 11 Suppl 3
DP  - 1997 Apr
TI  - Retinoid receptors in development and disease.
PG  - 376-7
AB  - Nuclear receptors comprise a large family of ligand-dependent transcription 
      factors that display considerable specificity in and selectivity in regulating 
      the genetic programs they ultimately influence. The response to retinoic acid 
      (RA) is mediated by two families of transcription factors which include the 
      retinoic acids receptors (RARs) and the retinoid X receptors (RXRs). In human 
      acute promyelocytic leukemia (APL), RAR alpha becomes an activated oncogene as a 
      consequence of its fusion to the PML locus. Because patients with APL can be 
      induced into remission with high dose RA therapy, we propose that PML-RAR is a 
      new class of dominant negative oncogene that disrupts a structure that includes 
      at least five other proteins. This mega-complex, referred to as a "POD", is 
      disrupted in leukemic cells expressing the oncoprotein and is reassembled 
      following high dose RA therapy in both cell culture an in patients.
FAU - Schulman, I G
AU  - Schulman IG
FAU - Evans, R M
AU  - Evans RM
LA  - eng
PT  - Journal Article
PL  - England
TA  - Leukemia
JT  - Leukemia
JID - 8704895
RN  - 0 (Antineoplastic Agents)
RN  - 0 (Neoplasm Proteins)
RN  - 0 (Nuclear Proteins)
RN  - 0 (Promyelocytic Leukemia Protein)
RN  - 0 (Receptors, Retinoic Acid)
RN  - 0 (Retinoid X Receptors)
RN  - 0 (Transcription Factors)
RN  - 0 (Tumor Suppressor Proteins)
RN  - 143220-95-5 (PML protein, human)
RN  - 5688UTC01R (Tretinoin)
SB  - IM
MH  - Aging
MH  - Animals
MH  - Antineoplastic Agents/pharmacology/therapeutic use
MH  - Cells, Cultured
MH  - Drosophila
MH  - Gene Expression Regulation/drug effects
MH  - Humans
MH  - Leukemia/drug therapy/genetics
MH  - Leukemia, Promyelocytic, Acute/*genetics
MH  - Models, Genetic
MH  - *Neoplasm Proteins
MH  - *Nuclear Proteins
MH  - *Oncogenes
MH  - Promyelocytic Leukemia Protein
MH  - Receptors, Retinoic Acid/*genetics/metabolism
MH  - Retinoid X Receptors
MH  - Transcription Factors/*genetics/metabolism
MH  - Tretinoin/pharmacology/therapeutic use
MH  - Tumor Cells, Cultured
MH  - Tumor Suppressor Proteins
EDAT- 1997/04/01 00:00
MHDA- 1997/04/01 00:01
CRDT- 1997/04/01 00:00
PHST- 1997/04/01 00:00 [pubmed]
PHST- 1997/04/01 00:01 [medline]
PHST- 1997/04/01 00:00 [entrez]
PST - ppublish
SO  - Leukemia. 1997 Apr;11 Suppl 3:376-7.