PMID- 9209889
OWN - NLM
STAT- MEDLINE
DCOM- 19970821
LR  - 20191102
IS  - 0906-6705 (Print)
IS  - 0906-6705 (Linking)
VI  - 6
IP  - 2
DP  - 1997 Apr
TI  - Significant reduction of human monocyte chemotactic response to 
      monocyte-chemotactic protein 1 in patients with primary and metastatic malignant 
      melanoma.
PG  - 81-6
AB  - The recruitment of leukocytes from the peripheral blood is a key event for the 
      development and composition of the inflammatory infiltrate in solid tumors and 
      tumor metastases like malignant melanoma. Tumor-infiltrating lymphocytes (TIL) 
      and tumor-associated macrophages (TAM) are thought to play a crucial role in 
      tumor immunosurveillance. In malignant melanoma expression and secretion of 
      monocyte-chemotactic protein 1 (MCP-1) have been demonstrated. MCP-1 serves as an 
      attractant for monocytes and activated T-cells. In this study we addressed the 
      question whether circulating monocytes show altered chemotaxis to MCP-1. 
      Therefore the chemotactic responsiveness of monocytes towards MCP-1 was 
      investigated in patients with primary and metastatic melanoma and compared to 
      patients with basal cell carcinoma and healthy persons. The results show that 
      monocytes from melanoma patients showed a significantly decreased chemotactic 
      migration towards MCP-1 while chemotaxis to the stimulus 
      N-formyl-methionyl-leucyl-phenylalanine (FMLP) remained normal. Patients with 
      basal cell carcinoma showed normal monocyte chemotaxis to all stimuli tested. In 
      primary melanoma, there was no relation of the number of TAM or TIL to the 
      decreased chemotaxis of circulating monocytes to MCP-1. From these data it can be 
      concluded that circulating monocytes from patients with primary and metastatic 
      melanoma show a MCP-1-specific decrease in chemotactic migration. This may be due 
      to deactivation or modulation of the MCP-1-receptor expression on these cells.
FAU - Muller, R
AU  - Muller R
AD  - Dept of Dermatology, University of Kiel, Germany.
FAU - Zheng, M
AU  - Zheng M
FAU - Mrowietz, U
AU  - Mrowietz U
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Denmark
TA  - Exp Dermatol
JT  - Experimental dermatology
JID - 9301549
RN  - 0 (Chemokine CCL2)
RN  - 59880-97-6 (N-Formylmethionine Leucyl-Phenylalanine)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - Carcinoma, Basal Cell/immunology/pathology
MH  - Chemokine CCL2/*pharmacology
MH  - Chemotaxis/*drug effects
MH  - Female
MH  - Humans
MH  - Male
MH  - Melanoma/*immunology/pathology
MH  - Middle Aged
MH  - Monocytes/*drug effects/physiology
MH  - N-Formylmethionine Leucyl-Phenylalanine/pharmacology
MH  - Neoplasm Metastasis
MH  - Skin Neoplasms/*immunology/pathology
EDAT- 1997/04/01 00:00
MHDA- 1997/04/01 00:01
CRDT- 1997/04/01 00:00
PHST- 1997/04/01 00:00 [pubmed]
PHST- 1997/04/01 00:01 [medline]
PHST- 1997/04/01 00:00 [entrez]
AID - 10.1111/j.1600-0625.1997.tb00151.x [doi]
PST - ppublish
SO  - Exp Dermatol. 1997 Apr;6(2):81-6. doi: 10.1111/j.1600-0625.1997.tb00151.x.