PMID- 9212354
OWN - NLM
STAT- MEDLINE
DCOM- 19970902
LR  - 20180216
IS  - 0301-0147 (Print)
IS  - 0301-0147 (Linking)
VI  - 27
IP  - 2
DP  - 1997 Mar-Apr
TI  - Low molecular weight heparin and unfractionated heparin for prevention of 
      thrombo-embolism in general surgery: a meta-analysis of randomised clinical 
      trials.
PG  - 65-74
AB  - Low molecular weight heparin (LMWH), unfractionated heparin (UFH) and warfarin 
      were compared with respect to efficacy and safety in the prevention of 
      thrombo-embolism in general surgery. Meta-analysis (MA) with a priori definition 
      of the MA protocol was used to combine the results from randomised trials with 
      patients who underwent general surgery and deep-vein thrombosis (DVT) prophylaxis 
      with LMWH, UFH or warfarin. Forty-four studies were identified for assessment and 
      33 were included, however, none for warfarin. For efficacy (DVT and pulmonary 
      embolism) and major bleeding, no significant difference between the LMWH- and 
      UFH-treated groups was demonstrated. The relative risk of minor bleedings for 
      LMWH versus UFH was 0.75 (0.64-0.88; 95% confidence interval) and is significant 
      (p < 0.05). Within the limitations of the MA, LMWH and UFH did not differ 
      significantly in terms of prevention of thrombo-embolism, but LMWH had a 
      significantly better safety profile. On this basis, LMWH may be preferable to UFH 
      in the prevention of thrombo-embolism in general surgery.
FAU - Palmer, A J
AU  - Palmer AJ
AD  - Institute for Medical Informatics and Biostatistics, Riehen, Switzerland.
FAU - Schramm, W
AU  - Schramm W
FAU - Kirchhof, B
AU  - Kirchhof B
FAU - Bergemann, R
AU  - Bergemann R
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PT  - Meta-Analysis
PT  - Research Support, Non-U.S. Gov't
PL  - Switzerland
TA  - Haemostasis
JT  - Haemostasis
JID - 0371574
RN  - 0 (Anticoagulants)
RN  - 0 (Heparin, Low-Molecular-Weight)
RN  - 9005-49-6 (Heparin)
SB  - IM
MH  - Anticoagulants/adverse effects/*therapeutic use
MH  - Hemorrhage/chemically induced
MH  - Heparin/adverse effects/*therapeutic use
MH  - Heparin, Low-Molecular-Weight/adverse effects/*therapeutic use
MH  - Humans
MH  - Postoperative Complications/*prevention & control
MH  - Randomized Controlled Trials as Topic
MH  - Thromboembolism/*prevention & control
MH  - Thrombophlebitis/*prevention & control
EDAT- 1997/03/01 00:00
MHDA- 1997/03/01 00:01
CRDT- 1997/03/01 00:00
PHST- 1997/03/01 00:00 [pubmed]
PHST- 1997/03/01 00:01 [medline]
PHST- 1997/03/01 00:00 [entrez]
AID - 10.1159/000217436 [doi]
PST - ppublish
SO  - Haemostasis. 1997 Mar-Apr;27(2):65-74. doi: 10.1159/000217436.