PMID- 9214425
OWN - NLM
STAT- MEDLINE
DCOM- 19970729
LR  - 20231213
IS  - 0004-3591 (Print)
IS  - 0004-3591 (Linking)
VI  - 40
IP  - 7
DP  - 1997 Jul
TI  - Usefulness of procalcitonin for differentiation between activity of systemic 
      autoimmune disease (systemic lupus erythematosus/systemic antineutrophil 
      cytoplasmic antibody-associated vasculitis) and invasive bacterial infection.
PG  - 1250-6
AB  - OBJECTIVE: To investigate whether the determination of serum procalcitonin (PCT) 
      in systemic autoimmune disease will help to discriminate invasive infection from 
      highly active underlying disease. METHODS: Three hundred ninety-seven serum 
      samples, from 18 patients with systemic lupus erythematosus (SLE) and 35 patients 
      with systemic antineutrophil cytoplasmic antibody-associated vasculitis (AAV), 
      were analyzed. Clinical disease activity was assessed by the Systemic Lupus 
      Activity Measure in SLE patients and by the Birmingham Vasculitis Activity Score 
      in AAV patients. Procalcitonin concentrations were determined in parallel with 
      concentrations of neopterin, interleukin-6 (IL-6), and C-reactive protein (CRP). 
      Additionally, serum creatinine values were obtained. RESULTS: In 321 of the 324 
      samples from the 42 patients with autoimmune disease but without systemic 
      infection, serum PCT levels were within the normal range (i.e., <0.5 ng/ml), 
      whereas the values for neopterin, IL-6, and CRP were elevated in patients with 
      active underlying disease. All 16 systemic infections occurred in 11 patients 
      with AAV, and were associated with PCT levels that were markedly elevated, to a 
      mean +/- SD of 1.93 +/- 1.19 ng/ml. No correlation between the degree of renal 
      impairment and PCT concentrations was seen. CONCLUSION: PCT may serve as a useful 
      marker for the detection of systemic bacterial infection in patients with 
      systemic autoimmune disease.
FAU - Eberhard, O K
AU  - Eberhard OK
AD  - Medizinische Hochschule Hannover, Germany.
FAU - Haubitz, M
AU  - Haubitz M
FAU - Brunkhorst, F M
AU  - Brunkhorst FM
FAU - Kliem, V
AU  - Kliem V
FAU - Koch, K M
AU  - Koch KM
FAU - Brunkhorst, R
AU  - Brunkhorst R
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Arthritis Rheum
JT  - Arthritis and rheumatism
JID - 0370605
RN  - 0 (Antibodies, Antineutrophil Cytoplasmic)
RN  - 0 (Biomarkers)
RN  - 0 (CALCA protein, human)
RN  - 0 (Glycoproteins)
RN  - 0 (Interleukin-6)
RN  - 0 (Protein Precursors)
RN  - 0 (Biopterins)
RN  - 670-65-5 (Neopterin)
RN  - 9007-12-9 (Calcitonin)
RN  - 9007-41-4 (C-Reactive Protein)
RN  - AYI8EX34EU (Creatinine)
RN  - JHB2QIZ69Z (Calcitonin Gene-Related Peptide)
SB  - IM
CIN - Arthritis Rheum. 1998 Mar;41(3):566-7; author reply 568. PMID: 9506590
CIN - Arthritis Rheum. 1998 Mar;41(3):567-8. PMID: 9506591
MH  - Antibodies, Antineutrophil Cytoplasmic/*analysis
MH  - Autoimmune Diseases/*diagnosis
MH  - Bacterial Infections/*diagnosis
MH  - Biomarkers/*blood
MH  - Biopterins/analogs & derivatives/blood
MH  - C-Reactive Protein/analysis
MH  - Calcitonin/*blood
MH  - Calcitonin Gene-Related Peptide
MH  - Creatinine/blood
MH  - Diagnosis, Differential
MH  - Glycoproteins/*blood
MH  - Granulomatosis with Polyangiitis/*diagnosis
MH  - Humans
MH  - Interleukin-6/blood
MH  - Lupus Erythematosus, Systemic/*diagnosis
MH  - Neopterin
MH  - Protein Precursors/*blood
MH  - Vasculitis/*diagnosis
EDAT- 1997/07/01 00:00
MHDA- 1997/07/01 00:01
CRDT- 1997/07/01 00:00
PHST- 1997/07/01 00:00 [pubmed]
PHST- 1997/07/01 00:01 [medline]
PHST- 1997/07/01 00:00 [entrez]
AID - 10.1002/1529-0131(199707)40:7<1250::AID-ART9>3.0.CO;2-A [doi]
PST - ppublish
SO  - Arthritis Rheum. 1997 Jul;40(7):1250-6. doi: 
      10.1002/1529-0131(199707)40:7<1250::AID-ART9>3.0.CO;2-A.