PMID- 9216211
OWN - NLM
STAT- MEDLINE
DCOM- 19970923
LR  - 20151119
IS  - 0301-1542 (Print)
IS  - 0301-1542 (Linking)
VI  - 34 Suppl
DP  - 1996 Dec
TI  - [Role of alveolar macrophages in the pathogenesis of idiopathic interstitial 
      pneumonia].
PG  - 175-80
AB  - To clarify role of alveolar macrophages in the pathogenesis of idiopathic 
      interstitial pneumonia (IIP), we studied (1) the localization and expression of 
      monocyte chemoattractant protein-1 (MCP-1) in IIP by immunohistochemistry and in 
      situ hybridization. (2) the role of MCP-1 in macrophage recruitment to be lung, 
      and (3) the clinical usefulness of measuring MCP-1. (1) In IIP, MCP-1 was 
      observed in cuboidal and flattened metaplastic epithelial cells, alveolar 
      macrophages, and vascular endothelial cells. In contrast, no epithelial cells 
      from patients without IIP stained positive for MCP-1, although alveolar 
      macrophages and vascular endothelial cells were labeled. MCP-1 production by 
      epithelial cells in IIP may be caused by the metaplastic nature of the epithelial 
      cells and may be a main cause of the irreversible progression of IIP. (2) MCP-1 
      levels in bronchoalveolar lavage fluid (BALF) were significantly higher in the 
      IIP, the interstitial pneumonia due to collagen vascular disease (IP-CVD) and 
      sarcoidosis groups than in normal controls. In the IIP group, the MCP-1 level was 
      significantly higher than in any other patient groups. In all three groups of 
      patients, the monocyte chemotactic activity in BALF correlated positively with 
      the MCP-1 levels in BALF, and were neutralized by anti-MCP-1. (3) BALF MCP-1 
      levels were significantly higher than serum MCP-1 levels in the IIP group, and 
      they were lower in the IP-CVD and non-specific interstitial pneumonia groups. 
      Serum MCP-1 levels reflected the activity of interstitial lung diseases, 
      especially during treatment with corticosteroids. These results indicate (1) that 
      MCP-1 plays a significant role in the recruitment of monocytes into the lung in 
      IIP, (2) that measuring MCP-1 levels both in BALF and in serum may help 
      discriminate IIP from other types of interstitial lung diseases, and (3) that 
      monitoring the serum MCP-1 level may be useful in estimating the activity of 
      interstitial lung diseases.
FAU - Suga, M
AU  - Suga M
AD  - First Department of Internal Medicine, Kumamoto University School of Medicine, 
      Japan.
FAU - Iyonaga, K
AU  - Iyonaga K
FAU - Ando, M
AU  - Ando M
LA  - jpn
PT  - English Abstract
PT  - Journal Article
PT  - Review
PL  - Japan
TA  - Nihon Kyobu Shikkan Gakkai Zasshi
JT  - Nihon Kyobu Shikkan Gakkai zasshi
JID - 7505737
RN  - 0 (Biomarkers)
RN  - 0 (Chemokine CCL2)
SB  - IM
MH  - Biomarkers/analysis
MH  - Bronchoalveolar Lavage Fluid/chemistry
MH  - Chemokine CCL2/*physiology
MH  - Endothelium, Vascular/metabolism
MH  - Humans
MH  - Lung Diseases, Interstitial/*etiology
MH  - Macrophages, Alveolar/*physiology
RF  - 5
EDAT- 1996/12/01 00:00
MHDA- 1996/12/01 00:01
CRDT- 1996/12/01 00:00
PHST- 1996/12/01 00:00 [pubmed]
PHST- 1996/12/01 00:01 [medline]
PHST- 1996/12/01 00:00 [entrez]
PST - ppublish
SO  - Nihon Kyobu Shikkan Gakkai Zasshi. 1996 Dec;34 Suppl:175-80.