PMID- 9216714
OWN - NLM
STAT- MEDLINE
DCOM- 19970801
LR  - 20190816
IS  - 0165-4608 (Print)
IS  - 0165-4608 (Linking)
VI  - 96
IP  - 2
DP  - 1997 Jul 15
TI  - A recurrent translocation, t(16;21)(q24;q22), associated with acute myelogenous 
      leukemia: identification by fluorescence in situ hybridization.
PG  - 102-5
AB  - Chromosome fluorescence in situ hybridization (FISH) analyses were performed on 
      bone marrow cells in 3 adult patients with MDS or AML with a (16;21)(q24;q22) 
      translocation. FISH analyses with AML1 probes at 21q22 proved in all 3 patients 
      splitting of the AML1 gene at a region spanning exons 5 and 6 and the 
      translocation of its 5' segment to distal 16q. Chromosome painting FISH analysis 
      in patient 1 proved the translocation of the distal 21q segment to 16q, but it 
      failed to prove the presumed translocation of the distal 16q segment to 21q, most 
      likely because of its small size.
FAU - Shimada, M
AU  - Shimada M
AD  - Center for Molecular Genetics and Cytogenetic Analysis, SRL, Inc., Tokyo, Japan.
FAU - Ohtsuka, E
AU  - Ohtsuka E
FAU - Shimizu, T
AU  - Shimizu T
FAU - Matsumoto, T
AU  - Matsumoto T
FAU - Matsushita, K
AU  - Matsushita K
FAU - Tanimoto, F
AU  - Tanimoto F
FAU - Kajii, T
AU  - Kajii T
LA  - eng
PT  - Case Reports
PT  - Journal Article
PL  - United States
TA  - Cancer Genet Cytogenet
JT  - Cancer genetics and cytogenetics
JID - 7909240
RN  - 0 (Core Binding Factor Alpha 2 Subunit)
RN  - 0 (DNA Probes)
RN  - 0 (DNA-Binding Proteins)
RN  - 0 (Proto-Oncogene Proteins)
RN  - 0 (RUNX1 protein, human)
RN  - 0 (Transcription Factors)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Bone Marrow/pathology
MH  - Chromosome Aberrations/*genetics
MH  - Chromosome Banding
MH  - Chromosome Disorders
MH  - *Chromosomes, Human, Pair 16
MH  - *Chromosomes, Human, Pair 21
MH  - Core Binding Factor Alpha 2 Subunit
MH  - DNA Probes
MH  - *DNA-Binding Proteins
MH  - Female
MH  - Humans
MH  - In Situ Hybridization, Fluorescence
MH  - Leukemia, Myeloid, Acute/*genetics
MH  - Male
MH  - Middle Aged
MH  - *Proto-Oncogene Proteins
MH  - Transcription Factors/*genetics
MH  - Translocation, Genetic
EDAT- 1997/07/15 00:00
MHDA- 1997/07/15 00:01
CRDT- 1997/07/15 00:00
PHST- 1997/07/15 00:00 [pubmed]
PHST- 1997/07/15 00:01 [medline]
PHST- 1997/07/15 00:00 [entrez]
AID - S0165-4608(96)00303-2 [pii]
AID - 10.1016/s0165-4608(96)00303-2 [doi]
PST - ppublish
SO  - Cancer Genet Cytogenet. 1997 Jul 15;96(2):102-5. doi: 
      10.1016/s0165-4608(96)00303-2.