PMID- 9216716
OWN - NLM
STAT- MEDLINE
DCOM- 19970801
LR  - 20190816
IS  - 0165-4608 (Print)
IS  - 0165-4608 (Linking)
VI  - 96
IP  - 2
DP  - 1997 Jul 15
TI  - Translocation (8;12;21)(q22.1;q24.1;q22.1): a new masked type of t(8;21)(q22;q22) 
      in a patient with acute myeloid leukemia.
PG  - 111-4
AB  - The translocation t(8;21)(q22;q22) is found in 40% of cases of acute myeloid 
      leukemia (AML) designated as the subtype M2 in the French-American-British (FAB) 
      classification. The 8;21 translocation is clinically of interest because patients 
      with this subtype have a good prognosis. We describe a masked type of the 
      translocation, t(8;12;21)(q22.1;q24.1;q22.1). The translocation was first 
      interpreted as t(8;12)(q22;q24) based on cytogenetics, but was reevaluated as a 
      result of Southern blot and fluorescence in situ hybridization (FISH) analyses.
FAU - Saitoh, K
AU  - Saitoh K
AD  - Third Department of Internal Medicine, Akita University School of Medicine, 
      Japan.
FAU - Miura, I
AU  - Miura I
FAU - Ohshima, A
AU  - Ohshima A
FAU - Takahashi, N
AU  - Takahashi N
FAU - Kume, M
AU  - Kume M
FAU - Utsumi, S
AU  - Utsumi S
FAU - Kobayashi, Y
AU  - Kobayashi Y
FAU - Hashimoto, K
AU  - Hashimoto K
FAU - Hatano, Y
AU  - Hatano Y
FAU - Nimura, T
AU  - Nimura T
FAU - Saito, M
AU  - Saito M
FAU - Enomoto, K
AU  - Enomoto K
FAU - Ohhira, M
AU  - Ohhira M
FAU - Shimizu, K
AU  - Shimizu K
FAU - Ohki, M
AU  - Ohki M
FAU - Miura, A B
AU  - Miura AB
LA  - eng
PT  - Case Reports
PT  - Journal Article
PL  - United States
TA  - Cancer Genet Cytogenet
JT  - Cancer genetics and cytogenetics
JID - 7909240
RN  - 0 (Core Binding Factor Alpha 2 Subunit)
RN  - 0 (DNA-Binding Proteins)
RN  - 0 (Proto-Oncogene Proteins)
RN  - 0 (RUNX1 protein, human)
RN  - 0 (Transcription Factors)
SB  - IM
MH  - Acute Disease
MH  - Chromosome Aberrations/*genetics
MH  - Chromosome Banding
MH  - Chromosome Disorders
MH  - *Chromosomes, Human, Pair 12
MH  - *Chromosomes, Human, Pair 21
MH  - *Chromosomes, Human, Pair 8
MH  - Core Binding Factor Alpha 2 Subunit
MH  - *DNA-Binding Proteins
MH  - Humans
MH  - In Situ Hybridization, Fluorescence
MH  - Leukemia, Myeloid/*genetics
MH  - Male
MH  - Middle Aged
MH  - *Proto-Oncogene Proteins
MH  - Restriction Mapping
MH  - Transcription Factors/genetics
MH  - Translocation, Genetic
EDAT- 1997/07/15 00:00
MHDA- 1997/07/15 00:01
CRDT- 1997/07/15 00:00
PHST- 1997/07/15 00:00 [pubmed]
PHST- 1997/07/15 00:01 [medline]
PHST- 1997/07/15 00:00 [entrez]
AID - S0165-4608(96)00320-2 [pii]
AID - 10.1016/s0165-4608(96)00320-2 [doi]
PST - ppublish
SO  - Cancer Genet Cytogenet. 1997 Jul 15;96(2):111-4. doi: 
      10.1016/s0165-4608(96)00320-2.