PMID- 9218995
OWN - NLM
STAT- MEDLINE
DCOM- 19970826
LR  - 20101118
IS  - 1045-2257 (Print)
IS  - 1045-2257 (Linking)
VI  - 19
IP  - 3
DP  - 1997 Jul
TI  - Inversion of chromosome 11 inv(11)(p15q22), as a recurring chromosomal aberration 
      associated with de novo and secondary myeloid malignancies: identification of a 
      P1 clone spanning the 11q22 breakpoint.
PG  - 150-5
AB  - We studied four patients with inv(11)(p15q22) associated with malignant myeloid 
      diseases by using fluorescence in situ hybridization (FISH) with phage and cosmid 
      probes mapped and ordered on 11q22-24. Two of the four patients had non-Hodgkin's 
      lymphoma or acute lymphoblastic leukemia as the primary malignancy and had 
      received cytotoxic chemotherapy, including topoisomerase II inhibitors. The other 
      two had de novo acute myeloid leukemia or myelodysplastic syndrome. FISH analysis 
      showed that all 11q breakpoints were located centromeric to the MLL gene and 
      between cosmids CN2900 and CN1323. We identified a yeast artificial chromosome 
      (YAC) clone that spanned the inv(11) breakpoints on 11q. From this YAC, we 
      identified a P1 clone, which included the breakpoints in at least three of the 
      four patients. It is highly likely that the same gene on the P1 clone is 
      rearranged in leukemic cells of each patient. This gene may be one of the targets 
      for topoisomerase II inhibitors.
FAU - Kobayashi, H
AU  - Kobayashi H
AD  - Third Clinical Department, Saitama Cancer Center Hospital, Japan.
FAU - Arai, Y
AU  - Arai Y
FAU - Hosoda, F
AU  - Hosoda F
FAU - Maseki, N
AU  - Maseki N
FAU - Hayashi, Y
AU  - Hayashi Y
FAU - Eguchi, H
AU  - Eguchi H
FAU - Ohki, M
AU  - Ohki M
FAU - Kaneko, Y
AU  - Kaneko Y
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Genes Chromosomes Cancer
JT  - Genes, chromosomes & cancer
JID - 9007329
RN  - 0 (Topoisomerase II Inhibitors)
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Anemia, Refractory, with Excess of Blasts/drug therapy/etiology/genetics
MH  - Antineoplastic Combined Chemotherapy Protocols/adverse effects/*pharmacology
MH  - Bacteriophage P1
MH  - Child
MH  - Child, Preschool
MH  - Chromosome Breakage
MH  - *Chromosome Inversion
MH  - Chromosome Mapping
MH  - Chromosomes, Artificial, Yeast
MH  - Chromosomes, Human, Pair 11/*genetics
MH  - Female
MH  - Genomic Library
MH  - Humans
MH  - In Situ Hybridization, Fluorescence
MH  - Karyotyping
MH  - Leukemia, Myeloid, Acute/drug therapy/etiology/genetics
MH  - Lymphoma, Non-Hodgkin/drug therapy/etiology/genetics
MH  - Male
MH  - Middle Aged
MH  - Myelodysplastic Syndromes/drug therapy/etiology/*genetics
MH  - Neoplasms, Second Primary/etiology/*genetics
MH  - Precursor Cell Lymphoblastic Leukemia-Lymphoma/drug therapy/etiology/genetics
MH  - *Topoisomerase II Inhibitors
EDAT- 1997/07/01 00:00
MHDA- 2000/06/20 09:00
CRDT- 1997/07/01 00:00
PHST- 1997/07/01 00:00 [pubmed]
PHST- 2000/06/20 09:00 [medline]
PHST- 1997/07/01 00:00 [entrez]
AID - 10.1002/(SICI)1098-2264(199707)19:3<150::AID-GCC3>3.0.CO;2-X [pii]
PST - ppublish
SO  - Genes Chromosomes Cancer. 1997 Jul;19(3):150-5.