PMID- 9220617
OWN - NLM
STAT- MEDLINE
DCOM- 19970912
LR  - 20200407
IS  - 0378-1135 (Print)
IS  - 1873-2542 (Electronic)
IS  - 0378-1135 (Linking)
VI  - 55
IP  - 1-4
DP  - 1997 Apr
TI  - Pathogenesis and clinical aspects of a respiratory porcine reproductive and 
      respiratory syndrome virus infection.
PG  - 223-30
AB  - Some pathogenetic and clinical aspects of the respiratory tract infection with 
      porcine reproductive and respiratory syndrome virus (PRRSV) are discussed. The 
      acute and persistent stages of PRRSV infection are treated separately. Special 
      attention is given to the author's work on experimental dual infections with 
      PRRSV and other enzootic porcine respiratory viruses. It was concluded that: (1) 
      Studies on the interactions of PRRSV and its target cell, the pulmonary alveolar 
      macrophage, are very scarce. So far, the hypothesis of impaired macrophage 
      function has not been proven. (2) The possibility that PRRSV causes disease in 
      growing pigs in combination with other viral or bacterial infections has been 
      demonstrated experimentally. Variation in disease resulting from such combined 
      PRRSV infections will probably hamper future research into disease mechanisms. 
      (3) There remains a need for more data on the clinicopathological significance of 
      the persistent stage of PRRSV infections.
FAU - Van Reeth, K
AU  - Van Reeth K
AD  - Laboratory of Veterinary Virology, Faculty of Veterinary Medicine, University of 
      Gent, Merelbeke, Belgium. maurice.pensaert@rug.ac.be
LA  - eng
PT  - Journal Article
PT  - Review
PL  - Netherlands
TA  - Vet Microbiol
JT  - Veterinary microbiology
JID - 7705469
SB  - IM
MH  - Acute Disease
MH  - Animals
MH  - Bacterial Infections/complications/veterinary
MH  - Chronic Disease
MH  - Macrophages, Alveolar/*virology
MH  - Porcine Reproductive and Respiratory Syndrome/pathology/*physiopathology
MH  - Porcine respiratory and reproductive syndrome virus/isolation & 
      purification/pathogenicity/*physiology
MH  - Swine
MH  - Swine Diseases
MH  - Virus Replication
PMC - PMC7117399
EDAT- 1997/04/01 00:00
MHDA- 1997/04/01 00:01
PMCR- 1998/01/05
CRDT- 1997/04/01 00:00
PHST- 1997/04/01 00:00 [pubmed]
PHST- 1997/04/01 00:01 [medline]
PHST- 1997/04/01 00:00 [entrez]
PHST- 1998/01/05 00:00 [pmc-release]
AID - S0378-1135(96)01331-4 [pii]
AID - 10.1016/s0378-1135(96)01331-4 [doi]
PST - ppublish
SO  - Vet Microbiol. 1997 Apr;55(1-4):223-30. doi: 10.1016/s0378-1135(96)01331-4.