PMID- 9220619
OWN - NLM
STAT- MEDLINE
DCOM- 19970912
LR  - 20200403
IS  - 0378-1135 (Print)
IS  - 1873-2542 (Electronic)
IS  - 0378-1135 (Linking)
VI  - 55
IP  - 1-4
DP  - 1997 Apr
TI  - Effect of porcine reproductive and respiratory syndrome virus on subsequent 
      Pasteurella multocida challenge in pigs.
PG  - 241-6
AB  - This trial was conducted to evaluate the effect of Porcine reproductive and 
      respiratory syndrome virus (PRRSv) on a subsequent challenge with Pasteurella 
      multocida in pigs. Sixteen, 3-4 week-old piglets, from a PRRSv and Aujeszky 
      disease virus (ADV) free herd were used. Animals were equally and randomly 
      allocated in four groups which were treated according the following schedule: 
      Group I: negative controls; Group II: inoculation with only PRRSV; Group III: 
      inoculation with PRRSV and P. multocida; Group IV: inoculation with ADV and P. 
      multocida (positive controls). PRRSV and ADV were inoculated intranasally, at the 
      doses of 10(4.6) and 10(4.5) TCID50/ml, respectively. Five days later, pigs from 
      groups III and IV were inoculated intranasally, with two ml of a 10(9) CFU/ml 
      suspension of equal parts of P. multocida, strains A52 and A24. No lesions were 
      observed in piglets of group I. Microscopically, interstitial pneumonia was 
      identified in all piglets of groups II and III and 3/4 piglets from group IV. 
      Bronchopneumonia was detected in 3/4 of the piglets from group III and in all 
      animals of group IV which, additionally, showed meningo-encephalitis and purulent 
      rhinitis. Macroscopically, only piglets of groups III and IV had lung 
      consolidation. However, much lower pneumonic scores (2.3%) were observed in group 
      III, where 3 of 4 piglets were affected. On the other hand, all piglets of group 
      IV showed some degree of pulmonary consolidation, with a mean score of 13.7%. 
      Based on these results, it appears that the role of PRRSV as a initiator of 
      secondary diseases is still undefined, but is probably mild. There was no clear 
      interaction between PRRSv and Pasteurella multocida under the conditions and 
      strains tested here.
FAU - Carvalho, L F
AU  - Carvalho LF
AD  - UNESP-Departamento de Clinica e Cirurgia, Jaboticabal, Sao Paulo, Brazil.
FAU - Segales, J
AU  - Segales J
FAU - Pijoan, C
AU  - Pijoan C
LA  - eng
PT  - Journal Article
PL  - Netherlands
TA  - Vet Microbiol
JT  - Veterinary microbiology
JID - 7705469
SB  - IM
MH  - Animals
MH  - Body Temperature
MH  - Lung/microbiology/pathology
MH  - Pasteurella Infections/complications/physiopathology/*veterinary
MH  - *Pasteurella multocida/isolation & purification
MH  - Porcine Reproductive and Respiratory Syndrome/pathology/*physiopathology
MH  - Porcine respiratory and reproductive syndrome virus/isolation & purification
MH  - Swine
MH  - *Swine Diseases
MH  - Time Factors
MH  - Trachea/microbiology
PMC - PMC7117206
EDAT- 1997/04/01 00:00
MHDA- 1997/04/01 00:01
PMCR- 1998/01/05
CRDT- 1997/04/01 00:00
PHST- 1997/04/01 00:00 [pubmed]
PHST- 1997/04/01 00:01 [medline]
PHST- 1997/04/01 00:00 [entrez]
PHST- 1998/01/05 00:00 [pmc-release]
AID - S0378-1135(96)01324-7 [pii]
AID - 10.1016/s0378-1135(96)01324-7 [doi]
PST - ppublish
SO  - Vet Microbiol. 1997 Apr;55(1-4):241-6. doi: 10.1016/s0378-1135(96)01324-7.