PMID- 9220620
OWN - NLM
STAT- MEDLINE
DCOM- 19970912
LR  - 20220330
IS  - 0378-1135 (Print)
IS  - 1873-2542 (Electronic)
IS  - 0378-1135 (Linking)
VI  - 55
IP  - 1-4
DP  - 1997 Apr
TI  - Porcine reproductive and respiratory syndrome virus (PRRSv) interaction with 
      Haemophilus parasuis.
PG  - 247-57
AB  - The interaction of bacteria and virus has been well demonstrated in the 
      pathogenesis of respiratory disease in swine. The interaction between porcine 
      respiratory and reproductive syndrome virus (PRRSv) and Haemophilus parasuis has 
      not been studied. We initiated studies to evaluate a possible effect of the PRRSv 
      on the pathogenesis of polyserositis caused by H. parasuis. A group of 30 three 
      week old piglets were distributed in 4 groups. Group I (10 pigs) was inoculated 
      with PRRSv and H. parasuis. Group II (10 pigs) was inoculated with H. parasuis 
      alone. Group III (5 pigs) was inoculated with virus alone and group IV (5 pigs) 
      was inoculated with culture media. Lesions consisted of a severe fibrinous 
      polyserositis affecting 7 of 10 animals in group II and a mild fibrinous 
      pleuritis in 1 of 10 animals of group I. Three of ten animals dually infected 
      with the two agents died during the course of the study. These animals had 
      pulmonary congestion and focal lung hemorrhages. No other animals died from other 
      groups. Group III and IV had no macroscopic lesions. Microscopically group III 
      had interstitial pneumonia. Immunomodulating virus effect may explain the 
      differences in terms of lesions severity between groups I and II. Septic shock 
      was suspected as cause of sudden death.
FAU - Solano, G I
AU  - Solano GI
AD  - College of Veterinary Medicine, University of Minnesota, St. Paul, USA.
FAU - Segales, J
AU  - Segales J
FAU - Collins, J E
AU  - Collins JE
FAU - Molitor, T W
AU  - Molitor TW
FAU - Pijoan, C
AU  - Pijoan C
LA  - eng
PT  - Journal Article
PL  - Netherlands
TA  - Vet Microbiol
JT  - Veterinary microbiology
JID - 7705469
SB  - IM
MH  - Animals
MH  - Body Temperature
MH  - Haemophilus/isolation & purification
MH  - Haemophilus Infections/complications/physiopathology/*veterinary
MH  - Lung/microbiology/pathology
MH  - Meninges/pathology
MH  - Porcine Reproductive and Respiratory Syndrome/pathology/*physiopathology
MH  - Swine
MH  - Swine Diseases
MH  - Time Factors
MH  - Trachea/microbiology/pathology
PMC - PMC7117440
EDAT- 1997/04/01 00:00
MHDA- 1997/04/01 00:01
PMCR- 1998/01/05
CRDT- 1997/04/01 00:00
PHST- 1997/04/01 00:00 [pubmed]
PHST- 1997/04/01 00:01 [medline]
PHST- 1997/04/01 00:00 [entrez]
PHST- 1998/01/05 00:00 [pmc-release]
AID - S0378-1135(96)01325-9 [pii]
AID - 10.1016/s0378-1135(96)01325-9 [doi]
PST - ppublish
SO  - Vet Microbiol. 1997 Apr;55(1-4):247-57. doi: 10.1016/s0378-1135(96)01325-9.