PMID- 9220622
OWN - NLM
STAT- MEDLINE
DCOM- 19970912
LR  - 20210119
IS  - 0378-1135 (Print)
IS  - 1873-2542 (Electronic)
IS  - 0378-1135 (Linking)
VI  - 55
IP  - 1-4
DP  - 1997 Apr
TI  - Immunity to PRRSV: double-edged sword.
PG  - 265-76
AB  - The immune system is a double-edged sword for porcine reproductive and 
      respiratory syndrome virus (PRRSV) infection. On one edge PRRSV has a 
      predilection for immune cells and the disease manifestations can be linked 
      directly to changes in the immune system. PRRSV appears to replicate extensively, 
      if not exclusively, in cells of the immune lineage, notably macrophages; the 
      direct replication of which may lead to immunosuppression, precipitate secondary 
      infection and/or mediate disease. On the other edge, the virus stimulates 
      immunity post-infection that protects an animal from re-infection. A vast array 
      of structural and functionally distinct antibody specific to PRRSV are generated 
      following infection or vaccination. Discrete populations of functional antibodies 
      appear at different times and possibly reflect reactivity to different PRRSV 
      polypeptides. Cell-mediated immune responses specific to PRRSV can be detected in 
      various exposed pigs as well. Thus, the immune system appears to be intimately 
      involved in both the disease process and protection from disease. It is unclear 
      at this state of understanding what immune compartment provides protective 
      immunity. It is humoral (i.e. antibodies), selective functionally distinct 
      populations of antibodies specific for selected PRRSV polypeptides or is cellular 
      immunity essential for protection, or both. This review will attempt to summarize 
      the current state of knowledge of the complex interaction of the immune system 
      and PRRSV.
FAU - Molitor, T W
AU  - Molitor TW
AD  - Department of Clinical and Population Sciences, College of Veterinary Medicine, 
      University of Minnesota, St. Paul 55108, USA.
FAU - Bautista, E M
AU  - Bautista EM
FAU - Choi, C S
AU  - Choi CS
LA  - eng
PT  - Journal Article
PT  - Review
PL  - Netherlands
TA  - Vet Microbiol
JT  - Veterinary microbiology
JID - 7705469
RN  - 0 (Viral Vaccines)
SB  - IM
MH  - Animals
MH  - Antibody Formation
MH  - Immune Tolerance
MH  - Immunity, Cellular
MH  - Lymphocyte Activation
MH  - Porcine Reproductive and Respiratory Syndrome/*immunology
MH  - Porcine respiratory and reproductive syndrome virus/*immunology/physiology
MH  - Swine
MH  - T-Lymphocytes/immunology
MH  - Viral Vaccines
MH  - Virus Replication
PMC - PMC7117121
EDAT- 1997/04/01 00:00
MHDA- 1997/04/01 00:01
PMCR- 1998/01/05
CRDT- 1997/04/01 00:00
PHST- 1997/04/01 00:00 [pubmed]
PHST- 1997/04/01 00:01 [medline]
PHST- 1997/04/01 00:00 [entrez]
PHST- 1998/01/05 00:00 [pmc-release]
AID - S0378-1135(96)01327-2 [pii]
AID - 10.1016/s0378-1135(96)01327-2 [doi]
PST - ppublish
SO  - Vet Microbiol. 1997 Apr;55(1-4):265-76. doi: 10.1016/s0378-1135(96)01327-2.