PMID- 9221380
OWN - NLM
STAT- MEDLINE
DCOM- 19970717
LR  - 20090407
IS  - 0934-8387 (Print)
IS  - 0934-8387 (Linking)
VI  - 51
IP  - 4
DP  - 1997 Apr
TI  - [Absence of association of specific and nonspecific bronchial hyperreactivity in 
      occupational asthma caused by platinum salts].
PG  - 345-50
AB  - There is evidence that bronchial responsiveness to allergen is quantitatively 
      correlated with bronchial responsiveness to nonspecific stimuli in subjects with 
      allergic asthma. This association has been questioned in occupational asthma due 
      to low molecular weight substances. It was the aim of this study to assess the 
      quantitative association of bronchial responsiveness to methacholine (MCH) and 
      platinum salts (Pt), in the form of hexachloroplatinic acid, in workers with 
      occupational asthma due to Pt salts. Fifty-seven subjects with exposure to Pt, 
      work-related asthma, and a positive bronchial challenge with Pt underwent skin 
      prick test with Pt and bronchial challenge with MCH. Using the provocation 
      concentration causing a > or = 50% fall in specific airway conductance 
      (PC50sGaw(Pt)) as a dependent variable, anamnestic data (period from first 
      symptoms to removal, period between removal from exposure and diagnosis, and 
      smoking), season of the investigation, skin prick tests with environmental 
      allergens, total immunoglobulin E (IgE), skin reactivity to Pt (Pt concentration 
      causing a 2 mm wheal), and PC50sGaw(MCH) were included as independent variables 
      for regression analysis. Fifty-two subjects (91%) showed a PC50sGaw(MCH) < 8 
      mg.mL-1 (geometric mean for all subjects 1.6 mg.mL-1). Responsiveness to Pt 
      varied widely between subjects (geometric mean of PC50sGaw(Pt) 9 x 10(-5) 
      mol.L-1, range 2 x 10(-7) to 10(-2) mol.L-1). There was no univariate correlation 
      between bronchial responsiveness to MCH and Pt, but there was a correlation 
      between skin reactivity to Pt and PC50sGaw(Pt) (r = 0.6). This association could 
      not be improved by considering PC50sGaw(MCH), the period from first symptoms to 
      removal, or the period between removal from exposure and diagnosis. The 
      parameters that showed the highest (negative) associations with PC50sGaw(Pt) were 
      skin reactivity to Pt and the period between removal from exposure and diagnosis 
      (r = 0.65). We conclude that there is a moderate association between bronchial 
      responsiveness to platinum salts and skin reactivity to platinum salts. However, 
      there is no association between methacholine responsiveness and bronchial 
      responsiveness to allergen in occupational asthma due to platinum salts.
FAU - Merget, R
AU  - Merget R
AD  - Abteilung fur Pneumologie, Allergologie und Schlafmedizin, Universitats-klinik, 
      Bochum.
FAU - Dierkes, A
AU  - Dierkes A
FAU - Ruckmann, A
AU  - Ruckmann A
FAU - Bergmann, E M
AU  - Bergmann EM
FAU - Schultze-Werninghaus, G
AU  - Schultze-Werninghaus G
LA  - ger
PT  - English Abstract
PT  - Journal Article
TT  - Fehlende Assoziation von spezifischer und unspezifischer bronchialer 
      Hyperreaktivitat beim Berufsasthma durch Platinsalze.
PL  - Germany
TA  - Pneumologie
JT  - Pneumologie (Stuttgart, Germany)
JID - 8906641
RN  - 0 (Air Pollutants, Occupational)
RN  - 0 (Platinum Compounds)
RN  - 37341-29-0 (Immunoglobulin E)
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Air Pollutants, Occupational/*adverse effects
MH  - Asthma/*chemically induced/diagnosis
MH  - Bronchial Hyperreactivity/*chemically induced/diagnosis
MH  - Bronchial Provocation Tests
MH  - Female
MH  - Forced Expiratory Volume/physiology
MH  - Humans
MH  - Immunoglobulin E/blood
MH  - Intradermal Tests
MH  - Male
MH  - Middle Aged
MH  - Occupational Diseases/*chemically induced/diagnosis
MH  - Platinum Compounds/*adverse effects
EDAT- 1997/04/01 00:00
MHDA- 1997/04/01 00:01
CRDT- 1997/04/01 00:00
PHST- 1997/04/01 00:00 [pubmed]
PHST- 1997/04/01 00:01 [medline]
PHST- 1997/04/01 00:00 [entrez]
PST - ppublish
SO  - Pneumologie. 1997 Apr;51(4):345-50.