PMID- 9221764
OWN - NLM
STAT- MEDLINE
DCOM- 19970814
LR  - 20190508
IS  - 0022-1007 (Print)
IS  - 1540-9538 (Electronic)
IS  - 0022-1007 (Linking)
VI  - 186
IP  - 2
DP  - 1997 Jul 21
TI  - Assembly and regulation of the CD40 receptor complex in human B cells.
PG  - 337-42
AB  - CD40 is a member of the tumor necrosis factor (TNF) receptor superfamily. Studies 
      with human B cells show that the binding of CD154 (gp39, CD40L) to CD40 recruits 
      TNF receptor- associated factor 2 (TRAF2) and TRAF3 to the receptor complex, 
      induces the downregulation of the nonreceptor-associated TRAFs in the cell and 
      induces an increased expression of Fas on the cell surface. Combined signaling 
      through the interluekin 4 receptor and CD40 induces an increased expression of 
      Fas with a commensurate increase in the level of TRAF2, but not TRAF3, that is 
      recruited to the receptor complex. In contrast, engagement of the membrane 
      immunoglobulin and CD40 limits Fas upregulation and reduces the recruitment of 
      TRAF2, relative to TRAF3, to the CD40 receptor complex. These studies show that 
      the TRAF composition of the CD40 receptor complex can be altered by signals that 
      influence B cell differentiation.
FAU - Kuhne, M R
AU  - Kuhne MR
AD  - Department of Microbiology, Dartmouth Medical School, Lebanon, New Hampshire 
      03756, USA.
FAU - Robbins, M
AU  - Robbins M
FAU - Hambor, J E
AU  - Hambor JE
FAU - Mackey, M F
AU  - Mackey MF
FAU - Kosaka, Y
AU  - Kosaka Y
FAU - Nishimura, T
AU  - Nishimura T
FAU - Gigley, J P
AU  - Gigley JP
FAU - Noelle, R J
AU  - Noelle RJ
FAU - Calderhead, D M
AU  - Calderhead DM
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - J Exp Med
JT  - The Journal of experimental medicine
JID - 2985109R
RN  - 0 (CD40 Antigens)
RN  - 0 (Membrane Glycoproteins)
RN  - 0 (Proteins)
RN  - 0 (TNF Receptor-Associated Factor 1)
RN  - 0 (TNF Receptor-Associated Factor 2)
RN  - 147205-72-9 (CD40 Ligand)
RN  - 207137-56-2 (Interleukin-4)
SB  - IM
MH  - B-Lymphocytes/*physiology
MH  - CD40 Antigens/chemistry/*metabolism
MH  - CD40 Ligand
MH  - Cells, Cultured
MH  - Humans
MH  - Interleukin-4/pharmacology
MH  - Membrane Glycoproteins/*metabolism
MH  - Proteins/*analysis
MH  - TNF Receptor-Associated Factor 1
MH  - TNF Receptor-Associated Factor 2
PMC - PMC2198982
EDAT- 1997/07/21 00:00
MHDA- 1997/07/21 00:01
PMCR- 1998/01/21
CRDT- 1997/07/21 00:00
PHST- 1997/07/21 00:00 [pubmed]
PHST- 1997/07/21 00:01 [medline]
PHST- 1997/07/21 00:00 [entrez]
PHST- 1998/01/21 00:00 [pmc-release]
AID - 10.1084/jem.186.2.337 [doi]
PST - ppublish
SO  - J Exp Med. 1997 Jul 21;186(2):337-42. doi: 10.1084/jem.186.2.337.