PMID- 9222021
OWN - NLM
STAT- MEDLINE
DCOM- 19970924
LR  - 20190512
IS  - 0268-1161 (Print)
IS  - 0268-1161 (Linking)
VI  - 12
IP  - 6
DP  - 1997 Jun
TI  - Chemokine and cyclooxygenase-2 expression in human endometrium coincides with 
      leukocyte accumulation.
PG  - 1300-6
AB  - The endometrium contains a resident population of leukocytes, the number and 
      subtype of which vary throughout the menstrual cycle and in early pregnancy. 
      Factors controlling these fluctuations are unknown, but a combination of 
      proliferation in situ and migration from the vasculature has been proposed. 
      Locally acting inflammatory mediators, including specific chemokines and 
      prostaglandins, have been implicated in these processes. Interleukin-8 (IL-8) and 
      monocyte chemoattractant protein-1 (MCP-1) are potent chemoattractants and 
      activators for neutrophils and monocytes respectively. Locally acting 
      prostaglandins modulate vascular permeability, and a synergistic action of 
      prostaglandin E (PGE) with IL-8 has been described. In the present study IL-8, 
      MCP-1 and cyclooxygenase-2 (COX-2), the inducible isoform of prostaglandin 
      synthase, were all localized in the endometrium by immunohistochemistry 
      throughout the menstrual cycle and in early pregnancy. All three inflammatory 
      mediators were localized to the perivascular cells of blood vessels in 
      endometrium and decidua, and additional immunoreactivity for COX-2 was identified 
      in the glandular epithelium. The intensity of immunostaining was reduced in the 
      periovulatory, early and mid-secretory phases and significantly increased 
      premenstrually. These results further support the hypothesis that there is a 
      premenstrual migration of leukocytes into the endometrium mediated by chemokines.
FAU - Jones, R L
AU  - Jones RL
AD  - Department of Obstetrics and Gynaecology, University of Edinburgh, UK.
FAU - Kelly, R W
AU  - Kelly RW
FAU - Critchley, H O
AU  - Critchley HO
LA  - eng
PT  - Journal Article
PL  - England
TA  - Hum Reprod
JT  - Human reproduction (Oxford, England)
JID - 8701199
RN  - 0 (Chemokine CCL2)
RN  - 0 (Chemokines)
RN  - 0 (Interleukin-8)
RN  - 0 (Isoenzymes)
RN  - 0 (Membrane Proteins)
RN  - EC 1.14.99.1 (Cyclooxygenase 2)
RN  - EC 1.14.99.1 (PTGS2 protein, human)
RN  - EC 1.14.99.1 (Prostaglandin-Endoperoxide Synthases)
SB  - IM
MH  - Chemokine CCL2/metabolism
MH  - Chemokines/*metabolism
MH  - Cyclooxygenase 2
MH  - Decidua/cytology/metabolism
MH  - Endometrium/*cytology/*metabolism
MH  - Female
MH  - Humans
MH  - Immunohistochemistry
MH  - Interleukin-8/metabolism
MH  - Isoenzymes/*metabolism
MH  - Leukocytes/*cytology
MH  - Membrane Proteins
MH  - Menstrual Cycle/metabolism
MH  - Pregnancy
MH  - Prostaglandin-Endoperoxide Synthases/*metabolism
EDAT- 1997/06/01 00:00
MHDA- 1997/06/01 00:01
CRDT- 1997/06/01 00:00
PHST- 1997/06/01 00:00 [pubmed]
PHST- 1997/06/01 00:01 [medline]
PHST- 1997/06/01 00:00 [entrez]
AID - 10.1093/humrep/12.6.1300 [doi]
PST - ppublish
SO  - Hum Reprod. 1997 Jun;12(6):1300-6. doi: 10.1093/humrep/12.6.1300.