PMID- 9224305
OWN - NLM
STAT- MEDLINE
DCOM- 19970815
LR  - 20041117
IS  - 0022-5347 (Print)
IS  - 0022-5347 (Linking)
VI  - 158
IP  - 2
DP  - 1997 Aug
TI  - Simultaneous chromosome 7 and 17 gain and sex chromosome loss provide evidence 
      that renal metanephric adenoma is related to papillary renal cell carcinoma.
PG  - 370-4
AB  - PURPOSE: Metanephric adenoma has recently been recognized as a unique renal tumor 
      characterized by an unusual degree of cellular differentiation and maturation. We 
      recently studied metanephric adenoma using metaphase analysis and observed 
      concomitant chromosome Y loss and chromosome 7 and 17 gain. To determine if these 
      chromosomal anomalies are consistently present in renal metanephric adenoma, we 
      studied all 11 tumors in the pathology tissue registry at our institution using 
      fluorescence in situ hybridization (FISH). MATERIALS AND METHODS: FISH, using 
      deoxyribonucleic acid probes for chromosomes 1, 7, 8, 17, X and Y, was performed 
      in isolated nuclei from 11 paraffin embedded renal metanephric adenoma specimens. 
      RESULTS: Of the 11 tumors (73%) 8 demonstrated chromosome 7 and 17 gain by FISH, 
      and the remaining 3 were found to have an apparently normal chromosomal content. 
      Of the 8 tumors (75%) from men showed 6 chromosome 7 and 17 gain with Y 
      chromosome loss. Of the 3 tumors (33%) from women 1 had chromosome 7 and 17 gain 
      with X chromosome loss, while 1 had chromosome 7 and 17 gain without sex 
      chromosome aneusomy. Metaphase analysis performed on 2 tumors revealed chromosome 
      7 and 17 gain and Y chromosome loss in 1, and no apparent, chromosome anomaly in 
      the other, confirming the results of FISH analysis. CONCLUSIONS: FISH analysis of 
      renal metanephric adenoma identified frequent chromosome 7 and 17 gain and sex 
      chromosome loss. These results are consistent with a clonal neoplastic disorder 
      in which chromosomes 7, 17, X and Y are likely to be involved in the pathogenesis 
      of this tumor. These characteristic chromosomal alterations have also been 
      observed in papillary renal cell adenoma and papillary renal cell carcinoma, 
      providing evidence that these tumors may be related.
FAU - Brown, J A
AU  - Brown JA
AD  - Department of Urology, Mayo Clinic, Rochester, Minnesota 55905, USA.
FAU - Anderl, K L
AU  - Anderl KL
FAU - Borell, T J
AU  - Borell TJ
FAU - Qian, J
AU  - Qian J
FAU - Bostwick, D G
AU  - Bostwick DG
FAU - Jenkins, R B
AU  - Jenkins RB
LA  - eng
PT  - Journal Article
PL  - United States
TA  - J Urol
JT  - The Journal of urology
JID - 0376374
SB  - IM
MH  - Adenoma/*genetics
MH  - Carcinoma, Papillary/*genetics
MH  - Carcinoma, Renal Cell/*genetics
MH  - Chromosome Aberrations/*genetics
MH  - Chromosomes, Human, Pair 1/genetics
MH  - Chromosomes, Human, Pair 17/*genetics
MH  - Chromosomes, Human, Pair 7/*genetics
MH  - Chromosomes, Human, Pair 8/genetics
MH  - Female
MH  - Humans
MH  - In Situ Hybridization, Fluorescence
MH  - Kidney Neoplasms/*genetics
MH  - Male
MH  - Sex Chromosomes/*genetics
EDAT- 1997/08/01 00:00
MHDA- 1997/08/01 00:01
CRDT- 1997/08/01 00:00
PHST- 1997/08/01 00:00 [pubmed]
PHST- 1997/08/01 00:01 [medline]
PHST- 1997/08/01 00:00 [entrez]
AID - S0022-5347(01)64482-3 [pii]
PST - ppublish
SO  - J Urol. 1997 Aug;158(2):370-4.