PMID- 9225377
OWN - NLM
STAT- MEDLINE
DCOM- 19970827
LR  - 20191102
IS  - 1323-1316 (Print)
IS  - 1323-1316 (Linking)
VI  - 51
IP  - 3
DP  - 1997 Jun
TI  - Identification of monocyte chemoattractant protein-1 in senile plaques and 
      reactive microglia of Alzheimer's disease.
PG  - 135-8
AB  - It has been shown that human monocytes express monocyte chemoattractant protein-1 
      (MCP-1), an inflammatory factor, in response to non-fibrillar beta-amyloid 
      protein. Reactive microglia and inflammatory factors were reported to be present 
      in beta-amyloid deposits (senile plaques) in Alzheimer's disease, suggesting the 
      presence of MCP-1 in senile plaques. To address this issue, we examined MCP-1 
      immunoreactivity in senile plaques using a mouse monoclonal anti-MCP-1 antibody. 
      Monocyte chemoattractant protein-1 was found immunohistochemically in mature 
      senile plaques and reactive microglia but not in immature senile plaques of brain 
      tissues from five patients with Alzheimer's disease. These findings suggest that 
      MCP-1-related inflammatory events induced by reactive microglia contribute to the 
      maturation of senile plaques.
FAU - Ishizuka, K
AU  - Ishizuka K
AD  - Department of Neuropsychiatry, Kumamoto University School of Medicine, Japan.
FAU - Kimura, T
AU  - Kimura T
FAU - Igata-yi, R
AU  - Igata-yi R
FAU - Katsuragi, S
AU  - Katsuragi S
FAU - Takamatsu, J
AU  - Takamatsu J
FAU - Miyakawa, T
AU  - Miyakawa T
LA  - eng
PT  - Journal Article
PL  - Australia
TA  - Psychiatry Clin Neurosci
JT  - Psychiatry and clinical neurosciences
JID - 9513551
RN  - 0 (Chemokine CCL2)
SB  - IM
MH  - Aged
MH  - Alzheimer Disease/*immunology/physiopathology
MH  - Brain Chemistry
MH  - Chemokine CCL2/*isolation & purification
MH  - Humans
MH  - Immunohistochemistry
MH  - Inflammation
MH  - Microglia/*immunology
MH  - Middle Aged
MH  - Neurofibrillary Tangles/*immunology
EDAT- 1997/06/01 00:00
MHDA- 1997/06/01 00:01
CRDT- 1997/06/01 00:00
PHST- 1997/06/01 00:00 [pubmed]
PHST- 1997/06/01 00:01 [medline]
PHST- 1997/06/01 00:00 [entrez]
AID - 10.1111/j.1440-1819.1997.tb02375.x [doi]
PST - ppublish
SO  - Psychiatry Clin Neurosci. 1997 Jun;51(3):135-8. doi: 
      10.1111/j.1440-1819.1997.tb02375.x.