PMID- 9226477
OWN - NLM
STAT- MEDLINE
DCOM- 19970912
LR  - 20190909
IS  - 0192-0561 (Print)
IS  - 0192-0561 (Linking)
VI  - 19
IP  - 1
DP  - 1997 Jan
TI  - Effects of interleukin-10 on water intake, locomotory activity, and rectal 
      temperature in rat treated with endotoxin.
PG  - 31-8
AB  - Intracerebroventricular (i.c.v.) interleukin-10 (25, 50, and 100 ng/rat) effects 
      on water intake, exploratory behaviour, and rectal temperature were evaluated in 
      rats treated intraperitoneally (i.p.) with lipopolysaccharide (0.32, 0.64, and 
      0.96 mg/kg). Endotoxin administration induced fever and inhibition of thirst in 
      water-deprived rats, and a decrease in lococomotory activity in normohydrated and 
      water-deprived animals. Our data show that interleukin-10 during 
      lipopolysaccharide administration controlled fever, increases exploratory 
      behaviour, but did not reverse lipopolysaccharide inhibition of thirst. These 
      effects suggest that fever, depression in locomotory activity but not inhibition 
      of thirst, induced by endotoxin are influenced by interleukin-10 levels.
FAU - Nava, F
AU  - Nava F
AD  - Institute of Pharmacology, School of Medicine, University of Messina, Italy.
FAU - Calapai, G
AU  - Calapai G
FAU - Facciola, G
AU  - Facciola G
FAU - Cuzzocrea, S
AU  - Cuzzocrea S
FAU - Marciano, M C
AU  - Marciano MC
FAU - De Sarro, A
AU  - De Sarro A
FAU - Caputi, A P
AU  - Caputi AP
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - Int J Immunopharmacol
JT  - International journal of immunopharmacology
JID - 7904799
RN  - 0 (Endotoxins)
RN  - 0 (Lipopolysaccharides)
RN  - 0 (Recombinant Proteins)
RN  - 130068-27-8 (Interleukin-10)
RN  - 67924-63-4 (endotoxin, Escherichia coli)
SB  - IM
MH  - Animals
MH  - Body Temperature/*drug effects
MH  - Endotoxins/*pharmacology/toxicity
MH  - Exploratory Behavior/*drug effects
MH  - Fever/chemically induced/physiopathology
MH  - Injections, Intraventricular
MH  - Interleukin-10/administration & dosage/metabolism/*pharmacology
MH  - Lipopolysaccharides/*pharmacology/toxicity
MH  - Locomotion/drug effects
MH  - Male
MH  - Rats
MH  - Rats, Sprague-Dawley
MH  - Recombinant Proteins/pharmacology
MH  - Th1 Cells/drug effects
MH  - Th2 Cells/metabolism
MH  - Thirst/*drug effects
EDAT- 1997/01/01 00:00
MHDA- 1997/01/01 00:01
CRDT- 1997/01/01 00:00
PHST- 1997/01/01 00:00 [pubmed]
PHST- 1997/01/01 00:01 [medline]
PHST- 1997/01/01 00:00 [entrez]
AID - S0192056197000064 [pii]
AID - 10.1016/s0192-0561(97)00006-4 [doi]
PST - ppublish
SO  - Int J Immunopharmacol. 1997 Jan;19(1):31-8. doi: 10.1016/s0192-0561(97)00006-4.