PMID- 9226745
OWN - NLM
STAT- MEDLINE
DCOM- 19970827
LR  - 20190726
IS  - 0033-3158 (Print)
IS  - 0033-3158 (Linking)
VI  - 131
IP  - 4
DP  - 1997 Jun
TI  - Abnormal ACTH and prolactin responses to fenfluramine in rats exposed to single 
      and multiple doses of MDMA.
PG  - 411-9
AB  - The present study examined the persistent functional consequences associated with 
      exposure to single and multiple doses of (+/-) 3,4-methylenedioxymethamphetamine 
      (MDMA) as reflected by the neuroendocrine responses to d,l-fenfluramine (FEN). 
      Adult male rats were administered a single dose of MDMA (20 mg/kg, s.c.) and 
      challenged 2 weeks later with saline or FEN (2, 4, 6 and 8 mg/kg, s.c.). The 
      corticotropin (ACTH) response to FEN (6 and 8 mg/kg) was blunted and the 
      prolactin response to FEN (4 and 6 mg/kg) was enhanced in MDMA pre-treated rats. 
      The ACTH and prolactin responses to FEN (6 mg/kg, s.c.) were then evaluated 4, 8 
      and 12 months after exposure to single and multiple doses MDMA (20 mg/kg, s.c. 
      and 20 mg/kg, s.c., bid, x 4 days, respectively). The ACTH response to FEN was 
      significantly reduced at 4 and 8 months in both MDMA treatment groups, and at 12 
      months in the multiple dose group only. In contrast, the prolactin response to 
      FEN was enhanced in both groups of MDMA treated rats at 4 months, but only in the 
      multiple dose group at 8 months. By 12 months, the prolactin response to FEN had 
      normalized. Following multiple doses of MDMA, 5-HT concentrations were reduced 
      significantly in the frontal cortex at 4 and 12 months. The results indicate that 
      exposure to single or multiple doses of MDMA can produce functional alterations 
      which can persist for months, whereas the biochemical sequelae were less robust 
      and shorter lived.
FAU - Poland, R E
AU  - Poland RE
AD  - Department of Psychiatry, Harbor-UCLA Medical Center, Torrance 90509, USA.
FAU - Lutchmansingh, P
AU  - Lutchmansingh P
FAU - McCracken, J T
AU  - McCracken JT
FAU - Zhao, J P
AU  - Zhao JP
FAU - Brammer, G L
AU  - Brammer GL
FAU - Grob, C S
AU  - Grob CS
FAU - Boone, K B
AU  - Boone KB
FAU - Pechnick, R N
AU  - Pechnick RN
LA  - eng
GR  - DA06863/DA/NIDA NIH HHS/United States
GR  - MH00534/MH/NIMH NIH HHS/United States
GR  - MH00722/MH/NIMH NIH HHS/United States
PT  - Journal Article
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - Germany
TA  - Psychopharmacology (Berl)
JT  - Psychopharmacology
JID - 7608025
RN  - 0 (Hallucinogens)
RN  - 0 (Serotonin Agents)
RN  - 2DS058H2CF (Fenfluramine)
RN  - 333DO1RDJY (Serotonin)
RN  - 9002-60-2 (Adrenocorticotropic Hormone)
RN  - 9002-62-4 (Prolactin)
RN  - KE1SEN21RM (N-Methyl-3,4-methylenedioxyamphetamine)
SB  - IM
MH  - Adrenocorticotropic Hormone/*blood/metabolism
MH  - Animals
MH  - Cerebral Cortex/drug effects
MH  - Dose-Response Relationship, Drug
MH  - Fenfluramine/*pharmacology
MH  - Hallucinogens/*pharmacology
MH  - Hippocampus/drug effects
MH  - Hypothalamus/drug effects
MH  - Male
MH  - N-Methyl-3,4-methylenedioxyamphetamine/*pharmacology
MH  - Prolactin/*blood/metabolism
MH  - Rats
MH  - Rats, Sprague-Dawley
MH  - Serotonin/*blood/metabolism
MH  - Serotonin Agents/*pharmacology
EDAT- 1997/06/01 00:00
MHDA- 1997/06/01 00:01
CRDT- 1997/06/01 00:00
PHST- 1997/06/01 00:00 [pubmed]
PHST- 1997/06/01 00:01 [medline]
PHST- 1997/06/01 00:00 [entrez]
AID - 10.1007/s002130050311 [doi]
PST - ppublish
SO  - Psychopharmacology (Berl). 1997 Jun;131(4):411-9. doi: 10.1007/s002130050311.