PMID- 9227865 OWN - NLM STAT- MEDLINE DCOM- 19970825 LR - 20210526 IS - 0893-8512 (Print) IS - 1098-6618 (Electronic) IS - 0893-8512 (Linking) VI - 10 IP - 3 DP - 1997 Jul TI - Human herpesvirus 6. PG - 521-67 AB - Human herpesvirus 6 variant A (HHV-6A) and human herpesvirus 6 variant B (HHV-6B) are two closely related yet distinct viruses. These visuses belong to the Roseolovirus genus of the betaherpesvirus subfamily; they are most closely related to human herpesvirus 7 and then to human cytomegalovirus. Over 95% of people older than 2 years of age are seropositive for either or both HHV-6 variants, and current serologic methods are incapable of discriminating infection with one variant from infection with the other. HHV-6A has not been etiologically linked to any human disease, but such an association will probably be found soon. HHV-6B is the etiologic agent of the common childhood illness exanthem subitum (roseola infantum or sixth disease) and related febrile illnesses. These viruses are frequently active and associated with illness in immunocompromised patients and may play a role in the etiology of Hodgkin's disease and other malignancies. HHV-6 is a commensal inhabitant of brains; various neurologic manifestations, including convulsions and encephalitis, can occur during primary HHV-6 infection or in immunocompromised patients. HHV-6 and distribution in the central nervous system are altered in patients with multiple sclerosis; the significance of this is under investigation. FAU - Braun, D K AU - Braun DK AD - Eli Lilly, Lilly Corporate Center, Indianapolis, Indiana 46285, USA. FAU - Dominguez, G AU - Dominguez G FAU - Pellett, P E AU - Pellett PE LA - eng PT - Journal Article PT - Review PL - United States TA - Clin Microbiol Rev JT - Clinical microbiology reviews JID - 8807282 SB - IM MH - Adult MH - Animals MH - Carcinoma/virology MH - Central Nervous System Diseases/virology MH - Child MH - Disease Models, Animal MH - Fatigue Syndrome, Chronic/virology MH - *Herpesviridae Infections/complications/diagnosis/epidemiology/genetics/therapy MH - *Herpesvirus 6, Human/classification/genetics/physiology MH - Hodgkin Disease/virology MH - Humans MH - Leukemia/virology MH - Lymphoma/virology MH - Multiple Sclerosis/virology MH - Sarcoma, Kaposi/virology MH - Virus Latency/physiology PMC - PMC172933 EDAT- 1997/07/01 00:00 MHDA- 1997/07/01 00:01 PMCR- 1997/07/01 CRDT- 1997/07/01 00:00 PHST- 1997/07/01 00:00 [pubmed] PHST- 1997/07/01 00:01 [medline] PHST- 1997/07/01 00:00 [entrez] PHST- 1997/07/01 00:00 [pmc-release] AID - 10.1128/CMR.10.3.521 [doi] PST - ppublish SO - Clin Microbiol Rev. 1997 Jul;10(3):521-67. doi: 10.1128/CMR.10.3.521.