PMID- 92319 OWN - NLM STAT- MEDLINE DCOM- 19800128 LR - 20190717 IS - 0004-3591 (Print) IS - 0004-3591 (Linking) VI - 22 IP - 11 DP - 1979 Nov TI - Placenta-bound immunoglobulins. PG - 1308-13 AB - Low pH eluates were prepared from trophoblasts derived from 8 term human placentas. A qualitative analysis for immunoglobulins revealed the presence of IgG, IgA, and IgM in these eluates. IgC-rich fractions were obtained by DEAE-cellulose chromatography of ammonium sulfate-concentrated eluates. These fractions were able to neutralize, in vitro, the catalytic activity of reverse transcriptases (RT) from several retroviruses. RT from baboon endogenous virus (BEV) seemed to be more susceptible to the neutralizing activity of some eluates. This was in contrast to RT from feline leukemia virus (FeLV) which were neutralized by eluates of leukocytes from chronic myelogenous leukemia. In contrast to previous and present results with purified IgG from leukemic leukocytes, the purified IgG from placenta eluates was incapable of RT neutralization. However, such purified IgG fractions inhibited mixed lymphocyte reactions. FAU - Jurjus, A AU - Jurjus A FAU - Wheeler, D A AU - Wheeler DA FAU - Gallo, R C AU - Gallo RC FAU - Witz, I P AU - Witz IP LA - eng PT - Journal Article PL - United States TA - Arthritis Rheum JT - Arthritis and rheumatism JID - 0370605 RN - 0 (Immunoglobulin G) RN - EC 2.7.7.49 (RNA-Directed DNA Polymerase) SB - IM MH - Female MH - Humans MH - Hydrogen-Ion Concentration MH - Immunoglobulin G/*analysis MH - Leukemia, Myeloid/immunology MH - Lymphocyte Culture Test, Mixed MH - Neutralization Tests MH - Placenta/*immunology MH - Pregnancy MH - RNA-Directed DNA Polymerase/metabolism MH - Retroviridae/enzymology MH - Trophoblasts/immunology/metabolism EDAT- 1979/11/01 00:00 MHDA- 1979/11/01 00:01 CRDT- 1979/11/01 00:00 PHST- 1979/11/01 00:00 [pubmed] PHST- 1979/11/01 00:01 [medline] PHST- 1979/11/01 00:00 [entrez] AID - 10.1002/art.1780221120 [doi] PST - ppublish SO - Arthritis Rheum. 1979 Nov;22(11):1308-13. doi: 10.1002/art.1780221120.