PMID- 9234214
OWN - NLM
STAT- MEDLINE
DCOM- 19970929
LR  - 20231213
IS  - 0165-0378 (Print)
IS  - 0165-0378 (Linking)
VI  - 33
IP  - 2
DP  - 1997 Jun
TI  - Immunologic activation during pregnancy: serial measurement of lymphocyte 
      phenotype and serum activation molecules in HIV-infected and uninfected women.
PG  - 157-70
AB  - Immunologic alterations occur during pregnancy, but the effect of pregnancy on 
      HIV infection is controversial. We characterized some of the immunologic 
      alterations with potential to influence HIV disease in 99 infected and 46 
      uninfected women during pregnancy and up to 6 months post-partum. 
      Immunophenotyping to quantitate the major lymphocyte subsets and determine 
      expression of activation and adhesion molecules on T cells was performed using 
      3-color staining and laser flow cytometry. Serum neopterin, beta 2-microglobulin, 
      and tumor necrosis factor-alpha (TNF alpha) were quantitated using commercial 
      immunoassays. HIV + pregnant women were compared to uninfected pregnant subjects 
      and to reference ranges established on healthy, HIV-seronegative non-pregnant 
      female controls. Both CD4 and CD8 T cell subsets were increased in HIV-negative 
      pregnant women compared to non-pregnant controls. In HIV-infected pregnant women, 
      CD4 T cells were low and CD8 cells were elevated compared to HIV-negative 
      pregnant and non-pregnant women. Levels of subsets were stable during pregnancy 
      and postpartum in both groups of women. Evidence of peripheral immune activation 
      was found during the later stages of pregnancy. Increases in HLA-DR and CD38 
      activation antigens on CD8 cells, serum neopterin and beta-2-microglobulin were 
      seen during pregnancy in HIV-negative women. These correlates of immune 
      activation were increased in HIV-infected pregnant women and increased further 
      during pregnancy, paralleling changes seen in uninfected pregnant women. These 
      immunologic alterations may directly or indirectly enhance viral replication, 
      impacting the long-term course of HIV disease.
FAU - Mikyas, Y
AU  - Mikyas Y
AD  - Department of Pediatrics, Marion Davies Children's Center, UCLA School of 
      Medicine 90095-1752, USA.
FAU - Aziz, N
AU  - Aziz N
FAU - Harawa, N
AU  - Harawa N
FAU - Gorre, M
AU  - Gorre M
FAU - Neagos, N
AU  - Neagos N
FAU - Nogueira, M
AU  - Nogueira M
FAU - Wafer, D
AU  - Wafer D
FAU - Dillon, M
AU  - Dillon M
FAU - Boyer, P J
AU  - Boyer PJ
FAU - Bryson, Y J
AU  - Bryson YJ
FAU - Plaeger, S
AU  - Plaeger S
LA  - eng
GR  - AI32440/AI/NIAID NIH HHS/United States
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - Ireland
TA  - J Reprod Immunol
JT  - Journal of reproductive immunology
JID - 8001906
RN  - 0 (Tumor Necrosis Factor-alpha)
RN  - 0 (beta 2-Microglobulin)
RN  - 0 (Biopterins)
RN  - 670-65-5 (Neopterin)
SB  - IM
MH  - Biopterins/analogs & derivatives/blood
MH  - CD4 Lymphocyte Count
MH  - CD4-Positive T-Lymphocytes/immunology
MH  - CD8-Positive T-Lymphocytes/immunology
MH  - Case-Control Studies
MH  - Female
MH  - HIV Infections/*complications/*immunology
MH  - Humans
MH  - Lymphocyte Activation
MH  - Neopterin
MH  - Phenotype
MH  - Postpartum Period/immunology
MH  - Pregnancy/*immunology
MH  - Pregnancy Complications, Infectious/*immunology
MH  - T-Lymphocyte Subsets/immunology
MH  - Tumor Necrosis Factor-alpha/biosynthesis
MH  - beta 2-Microglobulin/biosynthesis
EDAT- 1997/06/01 00:00
MHDA- 1997/06/01 00:01
CRDT- 1997/06/01 00:00
PHST- 1997/06/01 00:00 [pubmed]
PHST- 1997/06/01 00:01 [medline]
PHST- 1997/06/01 00:00 [entrez]
AID - S0165037897000181 [pii]
AID - 10.1016/s0165-0378(97)00018-1 [doi]
PST - ppublish
SO  - J Reprod Immunol. 1997 Jun;33(2):157-70. doi: 10.1016/s0165-0378(97)00018-1.