PMID- 9234216 OWN - NLM STAT- MEDLINE DCOM- 19970910 LR - 20190516 IS - 0916-7250 (Print) IS - 0916-7250 (Linking) VI - 59 IP - 6 DP - 1997 Jun TI - Structural organization and chromosomal assignment of the swine endothelin-1 gene. PG - 431-5 AB - Cosmid clone containing swine endothelin-1 (EDN1) gene, cosEDN1, was isolated from swine cosmid library using swine EDN1 cDNA as a probe. The sequence analysis of cosEDN1 DNA revealed that the swine EDN1 gene consists of 5 exons, spanning approximately 6.5 kb. In the 5'-upstream region of the EDN1 gene, AP-1 and NF-1 elements were found, suggesting the possibility that the expression of swine EDN1 gene is controlled by protooncogene products Fos and Jun, and TGF-beta. Fluorescence in situ hybridization (FISH) using cosEDN1 DNA as a probe demonstrated that EDN1 gene resides on swine chromosome 7p13- > pter. FAU - Kojima, M AU - Kojima M AD - Animal Genome Research Group, National Institute of Animal Industry, Norindanchi, Japan. FAU - Ohata, K AU - Ohata K FAU - Yasue, H AU - Yasue H LA - eng SI - GENBANK/X07383 PT - Journal Article PT - Research Support, Non-U.S. Gov't PL - Japan TA - J Vet Med Sci JT - The Journal of veterinary medical science JID - 9105360 RN - 0 (Endothelin-1) RN - 0 (Proto-Oncogene Proteins c-fos) RN - 0 (Proto-Oncogene Proteins c-jun) RN - 0 (Transforming Growth Factor beta) SB - IM MH - Animals MH - Base Sequence MH - *Chromosome Mapping MH - Clone Cells MH - Cosmids/*genetics MH - Endothelin-1/*genetics MH - *Gene Expression MH - In Situ Hybridization, Fluorescence MH - Molecular Sequence Data MH - Proto-Oncogene Proteins c-fos/physiology MH - Proto-Oncogene Proteins c-jun/physiology MH - Swine/*genetics MH - Transforming Growth Factor beta/physiology EDAT- 1997/06/01 00:00 MHDA- 1997/06/01 00:01 CRDT- 1997/06/01 00:00 PHST- 1997/06/01 00:00 [pubmed] PHST- 1997/06/01 00:01 [medline] PHST- 1997/06/01 00:00 [entrez] AID - 10.1292/jvms.59.431 [doi] PST - ppublish SO - J Vet Med Sci. 1997 Jun;59(6):431-5. doi: 10.1292/jvms.59.431.