PMID- 9236197
OWN - NLM
STAT- MEDLINE
DCOM- 19970815
LR  - 20240326
IS  - 0022-1007 (Print)
IS  - 1540-9538 (Electronic)
IS  - 0022-1007 (Linking)
VI  - 186
IP  - 3
DP  - 1997 Aug 4
TI  - Development of eosinophilic airway inflammation and airway hyperresponsiveness in 
      mast cell-deficient mice.
PG  - 449-54
AB  - Mast cells are the main effector cells of immediate hypersensitivity and 
      anaphylaxis. Their role in the development of allergen-induced airway 
      hyperresponsiveness (AHR) is controversial and based on indirect evidence. To 
      address these issues, mast cell-deficient mice (W/W v) and their congenic 
      littermates were sensitized to ovalbumin (OVA) by intraperitoneal injection and 
      subsequently challenged with OVA via the airways. Comparison of OVA-specific 
      immunoglobulin E (IgE) levels in the serum and numbers of eosinophils in 
      bronchoalveolar lavage fluid or lung digests showed no differences between the 
      two groups of mice. Further, measurements of airway resistance and dynamic 
      compliance at baseline and after inhalation of methacholine were similar. These 
      data indicate that mast cells or IgE-mast cell activation is not required for the 
      development of eosinophilic inflammation and AHR in mice sensitized to allergen 
      via the intraperitoneal route and challenged via the airways.
FAU - Takeda, K
AU  - Takeda K
AD  - Division of Basic Sciences and Pulmonary Medicine, Department of Pediatrics, 
      National Jewish Medical and Research Center, Denver, Colorado, USA.
FAU - Hamelmann, E
AU  - Hamelmann E
FAU - Joetham, A
AU  - Joetham A
FAU - Shultz, L D
AU  - Shultz LD
FAU - Larsen, G L
AU  - Larsen GL
FAU - Irvin, C G
AU  - Irvin CG
FAU - Gelfand, E W
AU  - Gelfand EW
LA  - eng
GR  - P01 HL036577/HL/NHLBI NIH HHS/United States
GR  - HL-36577/HL/NHLBI NIH HHS/United States
GR  - CA-20408/CA/NCI NIH HHS/United States
PT  - Journal Article
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - United States
TA  - J Exp Med
JT  - The Journal of experimental medicine
JID - 2985109R
RN  - 0 (Immunoglobulin G)
RN  - 37341-29-0 (Immunoglobulin E)
RN  - 9006-59-1 (Ovalbumin)
SB  - IM
MH  - Airway Resistance/immunology
MH  - Animals
MH  - Bronchial Hyperreactivity/*pathology/physiopathology
MH  - Bronchoalveolar Lavage Fluid/immunology
MH  - Eosinophils/*pathology
MH  - Female
MH  - Immunoglobulin E/biosynthesis
MH  - Immunoglobulin G/biosynthesis
MH  - Lung/immunology/pathology
MH  - Lung Compliance/immunology
MH  - Mast Cells/immunology/*pathology
MH  - Mice
MH  - Mice, Inbred C57BL
MH  - Mice, Mutant Strains
MH  - Ovalbumin/administration & dosage/immunology
PMC - PMC2198995
EDAT- 1997/08/04 00:00
MHDA- 1997/08/04 00:01
PMCR- 1998/02/04
CRDT- 1997/08/04 00:00
PHST- 1997/08/04 00:00 [pubmed]
PHST- 1997/08/04 00:01 [medline]
PHST- 1997/08/04 00:00 [entrez]
PHST- 1998/02/04 00:00 [pmc-release]
AID - 10.1084/jem.186.3.449 [doi]
PST - ppublish
SO  - J Exp Med. 1997 Aug 4;186(3):449-54. doi: 10.1084/jem.186.3.449.