PMID- 9237023
OWN - NLM
STAT- MEDLINE
DCOM- 19970904
LR  - 20191024
IS  - 0954-6928 (Print)
IS  - 0954-6928 (Linking)
VI  - 8
IP  - 3-4
DP  - 1997 Mar-Apr
TI  - Altered plasma levels of cytokines in patients with ischemic heart disease.
PG  - 143-7
AB  - BACKGROUND: Cytokines play an important role in mediating 
      inflammatory-proliferative responses, including atherosclerosis. Alterations in 
      the plasma levels of cytokines in patients with ischemic heart disease (IHD) 
      remain to be examined. OBJECTIVE: To examine the possible alterations in the 
      plasma levels of cytokines in patients with IHD and in controls. METHODS: 
      Thirty-one patients with IHD and 16 controls were studied. The cytokines measured 
      in our study included interleukin-6, macrophage-colony-stimulating factor (MCSF), 
      transforming growth factor-beta (TGF-beta), and seven other major cytokines. The 
      measurements were performed by using an enzyme-linked immunosorbent assay method. 
      RESULTS: The MCSF levels were significantly higher in patients with IHD than they 
      were in controls (P < 0.01), whereas the TGF-beta levels were significantly lower 
      in patients with IHD than they were in controls (P < 0.01). Moreover, the levels 
      of MCSF and those of TGF-beta were correlated negatively (P < 0.05). The 
      interleukin-6 levels tended to be higher in patients with unstable angina. The 
      plasma levels of other cytokines were below the detection levels in most cases. 
      CONCLUSIONS: Results from studies in vitro suggested that the process of 
      atherosclerosis is accelerated and inhibited by MCSF and TGF-beta, respectively. 
      The present results thus suggest that the alterations in the plasma levels of 
      MCSF and TGF-beta may be involved in the pathogenesis of IHD in humans.
FAU - Tashiro, H
AU  - Tashiro H
AD  - Department of Cardiology, St Mary Hospital, Kurume, Japan.
FAU - Shimokawa, H
AU  - Shimokawa H
FAU - Yamamoto, K
AU  - Yamamoto K
FAU - Momohara, M
AU  - Momohara M
FAU - Tada, H
AU  - Tada H
FAU - Takeshita, A
AU  - Takeshita A
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - Coron Artery Dis
JT  - Coronary artery disease
JID - 9011445
RN  - 0 (Biomarkers)
RN  - 0 (Cytokines)
RN  - 0 (Interleukin-6)
RN  - 0 (Transforming Growth Factor beta)
RN  - 81627-83-0 (Macrophage Colony-Stimulating Factor)
SB  - IM
MH  - Aged
MH  - Biomarkers/blood
MH  - Cytokines/*blood
MH  - Enzyme-Linked Immunosorbent Assay
MH  - Female
MH  - Humans
MH  - Interleukin-6/blood
MH  - Macrophage Colony-Stimulating Factor/blood
MH  - Male
MH  - Middle Aged
MH  - Myocardial Ischemia/*blood
MH  - Regression Analysis
MH  - Risk Factors
MH  - Transforming Growth Factor beta/blood
EDAT- 1997/03/01 00:00
MHDA- 1997/03/01 00:01
CRDT- 1997/03/01 00:00
PHST- 1997/03/01 00:00 [pubmed]
PHST- 1997/03/01 00:01 [medline]
PHST- 1997/03/01 00:00 [entrez]
AID - 10.1097/00019501-199703000-00004 [doi]
PST - ppublish
SO  - Coron Artery Dis. 1997 Mar-Apr;8(3-4):143-7. doi: 
      10.1097/00019501-199703000-00004.