PMID- 9237156
OWN - NLM
STAT- MEDLINE
DCOM- 19970924
LR  - 20190920
IS  - 0169-5002 (Print)
IS  - 0169-5002 (Linking)
VI  - 17
IP  - 2-3
DP  - 1997 Jul
TI  - Serum hepatocyte growth factor/scatter factor levels in small cell lung cancer 
      patients.
PG  - 211-8
AB  - Serum hepatocyte growth factor/scatter factor (HGF/SF) levels were measured in 25 
      patients with small cell lung cancer (SCLC), 16 patients with benign lung 
      diseases and 15 healthy subjects with an enzyme-linked immunosorbent assay. The 
      patients with SCLC did not have bacterial or interstitial pneumonia. Patients 
      with benign lung diseases included eight with bacterial pneumonia, three with 
      interstitial pneumonia, and five with benign lung tumor. Serum HGF/SF levels were 
      significantly higher in patients with SCLC (mean +/- S.D.: 0.40 +/- 0.17 ng/ml) 
      than in healthy subjects (0.26 +/- 0.093 ng/ml) (P = 0.0083). Patients with 
      bacterial pneumonia had significantly higher serum HGF/SF (0.52 +/- 0.19 ng/ml) 
      than did those with benign lung tumors (0.27 +/- 0.058 ng/ml) and healthy 
      subjects (P = 0.013 and P = 0.0019, respectively). By clinical stage of SCLC, 
      HGF/SF levels were 0.34 +/- 0.12 and 0.47 +/- 0.20 ng/ml in patients with limited 
      disease and extensive disease, respectively; this difference was not significant 
      (P = 0.080). Although serum HGF/SF levels were increased in patients with SCLC, 
      this increase might not have been related to tumor burden.
FAU - Takigawa, N
AU  - Takigawa N
AD  - Department of Medicine and Clinical Research, National Shikoku Cancer Center 
      Hospital, Matsuyama, Japan. ntakigaw@shikokucc.go.jp
FAU - Segawa, Y
AU  - Segawa Y
FAU - Maeda, Y
AU  - Maeda Y
FAU - Takata, I
AU  - Takata I
FAU - Fujimoto, N
AU  - Fujimoto N
LA  - eng
PT  - Journal Article
PL  - Ireland
TA  - Lung Cancer
JT  - Lung cancer (Amsterdam, Netherlands)
JID - 8800805
RN  - 0 (Biomarkers, Tumor)
RN  - 0 (Carcinoembryonic Antigen)
RN  - 67256-21-7 (Hepatocyte Growth Factor)
RN  - 9007-41-4 (C-Reactive Protein)
RN  - EC 1.1.1.27 (L-Lactate Dehydrogenase)
RN  - EC 4.2.1.11 (Phosphopyruvate Hydratase)
SB  - IM
MH  - Adult
MH  - Age Factors
MH  - Aged
MH  - Aged, 80 and over
MH  - Biomarkers, Tumor/blood
MH  - C-Reactive Protein/analysis
MH  - Carcinoembryonic Antigen/blood
MH  - Carcinoma, Small Cell/*blood
MH  - Enzyme-Linked Immunosorbent Assay
MH  - Female
MH  - Hepatocyte Growth Factor/*blood
MH  - Humans
MH  - L-Lactate Dehydrogenase/blood
MH  - Lung Diseases/*blood
MH  - Lung Neoplasms/*blood
MH  - Male
MH  - Middle Aged
MH  - Phosphopyruvate Hydratase/blood
MH  - Sensitivity and Specificity
MH  - Sex Factors
EDAT- 1997/07/01 00:00
MHDA- 1997/07/01 00:01
CRDT- 1997/07/01 00:00
PHST- 1997/07/01 00:00 [pubmed]
PHST- 1997/07/01 00:01 [medline]
PHST- 1997/07/01 00:00 [entrez]
AID - S0169-5002(97)00651-X [pii]
AID - 10.1016/s0169-5002(97)00651-x [doi]
PST - ppublish
SO  - Lung Cancer. 1997 Jul;17(2-3):211-8. doi: 10.1016/s0169-5002(97)00651-x.