PMID- 9238002
OWN - NLM
STAT- MEDLINE
DCOM- 19970908
LR  - 20190501
IS  - 0027-8424 (Print)
IS  - 1091-6490 (Electronic)
IS  - 0027-8424 (Linking)
VI  - 94
IP  - 16
DP  - 1997 Aug 5
TI  - RAC3, a steroid/nuclear receptor-associated coactivator that is related to SRC-1 
      and TIF2.
PG  - 8479-84
AB  - Steroids, thyroid hormones, vitamin D3, and retinoids are lipophilic small 
      molecules that regulate diverse biological effects such as cell differentiation, 
      development, and homeostasis. The actions of these hormones are mediated by 
      steroid/nuclear receptors which function as ligand-dependent transcriptional 
      regulators. Transcriptional activation by ligand-bound receptors is a complex 
      process requiring dissociation and recruitment of several additional cofactors. 
      We report here the cloning and characterization of receptor-associated 
      coactivator 3 (RAC3), a human transcriptional coactivator for steroid/nuclear 
      receptors. RAC3 interacts with several liganded receptors through a mechanism 
      which requires their respective ligand-dependent activation domains. RAC3 can 
      activate transcription when tethered to a heterologous DNA-binding domain. 
      Overexpression of RAC3 enhances the ligand-dependent transcriptional activation 
      by the receptors in mammalian cells. Sequence analysis reveals that RAC3 is 
      related to steroid receptor coactivator 1 (SRC-1) and transcriptional 
      intermediate factor 2 (TIF2), two of the most potent coactivators for 
      steroid/nuclear receptors. Thus, RAC3 is a member of a growing coactivator 
      network that should be useful as a tool for understanding hormone action and as a 
      target for developing new therapeutic agents that can block hormone-dependent 
      neoplasia.
FAU - Li, H
AU  - Li H
AD  - Department of Pharmacology and Molecular Toxicology, University of Massachusetts 
      Medical School, 55 Lake Avenue North, Worcester, MA 01655-0126, USA.
FAU - Gomes, P J
AU  - Gomes PJ
FAU - Chen, J D
AU  - Chen JD
LA  - eng
SI  - GENBANK/AF010227
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Proc Natl Acad Sci U S A
JT  - Proceedings of the National Academy of Sciences of the United States of America
JID - 7505876
RN  - 0 (NCOA2 protein, human)
RN  - 0 (Nuclear Receptor Coactivator 2)
RN  - 0 (Receptors, Steroid)
RN  - 0 (Trans-Activators)
RN  - 0 (Transcription Factors)
RN  - EC 2.3.1.48 (Histone Acetyltransferases)
RN  - EC 2.3.1.48 (NCOA1 protein, human)
RN  - EC 2.3.1.48 (Nuclear Receptor Coactivator 1)
RN  - EC 2.3.1.48 (Nuclear Receptor Coactivator 3)
SB  - IM
MH  - Amino Acid Sequence
MH  - Animals
MH  - Cell Line
MH  - Cloning, Molecular
MH  - Histone Acetyltransferases
MH  - Humans
MH  - Infant
MH  - Molecular Sequence Data
MH  - Nuclear Receptor Coactivator 1
MH  - Nuclear Receptor Coactivator 2
MH  - Nuclear Receptor Coactivator 3
MH  - Receptors, Steroid/*metabolism
MH  - Sequence Alignment
MH  - Sequence Analysis
MH  - Trans-Activators/*genetics/metabolism
MH  - Transcription Factors/*genetics/metabolism
MH  - Transfection
PMC - PMC22964
EDAT- 1997/08/05 00:00
MHDA- 1997/08/05 00:01
PMCR- 1998/02/05
CRDT- 1997/08/05 00:00
PHST- 1997/08/05 00:00 [pubmed]
PHST- 1997/08/05 00:01 [medline]
PHST- 1997/08/05 00:00 [entrez]
PHST- 1998/02/05 00:00 [pmc-release]
AID - 1282 [pii]
AID - 10.1073/pnas.94.16.8479 [doi]
PST - ppublish
SO  - Proc Natl Acad Sci U S A. 1997 Aug 5;94(16):8479-84. doi: 
      10.1073/pnas.94.16.8479.