PMID- 9241748
OWN - NLM
STAT- MEDLINE
DCOM- 19970911
LR  - 20061115
IS  - 0340-6245 (Print)
IS  - 0340-6245 (Linking)
VI  - 77
IP  - 6
DP  - 1997 Jun
TI  - The anticoagulant and hemorrhagic effects of DHG, a new depolymerized holothurian 
      glycosaminoglycan, on experimental hemodialysis in dogs.
PG  - 1148-53
AB  - We studied the use of depolymerized holothurian glycosaminoglycan (DHG) as an 
      anticoagulant in experimental beagle-dog hemodialysis using a hollow-fiber 
      dialyzer compared to that using unfractionated heparin (UFH), 
      low-molecular-weight heparin (LMWH), and nafamostat mesilate (FUT). Effectiveness 
      was based on 5 h hemodialysis and no marked clot deposition in the extracorporeal 
      circuit. At effective doses, UFH and LMWH significantly prolonged template 
      bleeding time, in sharp contrast to FUT and DHG, which scarcely prolonged 
      bleeding time during hemodialysis. DHG prolonged activated partial thromboplastin 
      time (APTT) about 6 times that of normal plasma and prolonged thrombin clotting 
      time (TCT) markedly; FUT showed marked APTT prolongation but hardly prolonged TCT 
      in the hemodialysis circuit at the effective dose. The anticoagulant profile of 
      DHG thus differs completely from that of FUT. These results suggest that DHG may 
      be useful as anticoagulant for hemodialysis with low hemorrhagic risk.
FAU - Minamiguchi, K
AU  - Minamiguchi K
AD  - Taiho Pharmaceutical Co., Ltd., Tokushima, Japan.
FAU - Kitazato, K T
AU  - Kitazato KT
FAU - Sasaki, E
AU  - Sasaki E
FAU - Nagase, H
AU  - Nagase H
FAU - Kitazato, K
AU  - Kitazato K
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PL  - Germany
TA  - Thromb Haemost
JT  - Thrombosis and haemostasis
JID - 7608063
RN  - 0 (Anticoagulants)
RN  - 0 (Glycosaminoglycans)
RN  - 0 (Heparin, Low-Molecular-Weight)
RN  - 9005-49-6 (Heparin)
SB  - IM
MH  - Animals
MH  - Anticoagulants/*administration & dosage
MH  - Dogs
MH  - Glycosaminoglycans/*administration & dosage
MH  - Heparin/administration & dosage
MH  - Heparin, Low-Molecular-Weight/administration & dosage
MH  - *Renal Dialysis
EDAT- 1997/06/01 00:00
MHDA- 1997/06/01 00:01
CRDT- 1997/06/01 00:00
PHST- 1997/06/01 00:00 [pubmed]
PHST- 1997/06/01 00:01 [medline]
PHST- 1997/06/01 00:00 [entrez]
PST - ppublish
SO  - Thromb Haemost. 1997 Jun;77(6):1148-53.